Kattner Simone, Herbstreit Frank, Schmidt Karsten, Stevens Philip, Grumaz Silke, Dubler Simon, Rath Peter-Michael, Brenner Thorsten
From the Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Noscendo GmbH, Duisburg, Germany.
A A Pract. 2021 May 6;15(5):e01447. doi: 10.1213/XAA.0000000000001447.
Aspergillus spp. are widespread environmental pathogens that can induce invasive aspergillosis, especially in immunocompromised patients. An 86-year-old female patient presented with a rare case of invasive cerebral aspergillosis. The aspergilloma invaded the intracranial region originating from the ethmoidal sinus and the orbital apex. In contrast to routine diagnostic procedures, next-generation sequencing (NGS) was able to identify the fungal pathogen in the cerebrospinal fluid as well as in plasma samples, supporting the biopsy-based diagnosis of invasive cerebral aspergillosis. Therefore, NGS-based diagnostics may be of particular importance for difficult-to-diagnose disease states, when conventional diagnostic procedures fail.
曲霉菌属是广泛存在的环境病原体，可引发侵袭性曲霉病，尤其是在免疫功能低下的患者中。一名86岁女性患者出现了罕见的侵袭性脑曲霉病病例。曲菌球起源于筛窦和眶尖，侵入了颅内区域。与常规诊断程序不同，新一代测序（NGS）能够在脑脊液以及血浆样本中识别出真菌病原体，支持了基于活检的侵袭性脑曲霉病诊断。因此，当传统诊断程序失败时，基于NGS的诊断对于难以诊断的疾病状态可能尤为重要。
