内向整流钾通道中的非常规电压感应。
Unconventional voltage sensing in an inwardly rectifying potassium channel.
机构信息
Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
出版信息
J Gen Physiol. 2021 Jun 7;153(6). doi: 10.1085/jgp.202112929. Epub 2021 May 6.
Abstract
Inwardly rectifying potassium channels are generally thought to achieve their physiological voltage dependence via an “extrinsic” mechanism involving voltage-dependent block by polyamines. A surprising finding of polyamine-independent gating of Kir4.1/Kir5.1 heteromeric channels suggests a mechanism of voltage dependence arising from interactions with permeating ions.
摘要
内向整流钾通道通常被认为通过一种“外在”机制实现其生理电压依赖性，该机制涉及多胺的电压依赖性阻断。令人惊讶的是，多胺不依赖的 Kir4.1/Kir5.1 异源二聚体通道门控的发现表明，电压依赖性的机制源自与渗透离子的相互作用。
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