Dogan Keziban, Kural Alev, Oztoprak Yasin, Dogan Murat
University of Health Sciences, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
University of Health Sciences, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey.
Hypertens Pregnancy. 2021 Aug;40(3):186-192. doi: 10.1080/10641955.2021.1921793. Epub 2021 May 6.
The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.
这项前瞻性研究于2020年2月至2020年12月在大学医院进行。研究人群（n = 88）包括后来发生肺栓塞（PE）的女性（n = 42）以及妊娠中期出生时健康的女性（n = 46）。比较了两组之间血清CRP、IL-1β、尿酸、肌酐、AST、ALT、MPV、Hb、PC、维生素D、钙和镁的水平。最终发生PE的受试者血清IL-1β和尿酸水平显著高于未发生PE的受试者。IL-1β和尿酸可能是PE的预测标志物。妊娠中期孕妇血清IL-1β和尿酸水平可能是PE的预测标志物。
