Brumfitt W, James I, Hamilton-Miller J M, Grady D, Price C
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London.
Biopharm Drug Dispos. 1988 May-Jun;9(3):251-7. doi: 10.1002/bod.2510090303.
Three different intramuscular formulations of cefonicid (a new long acting cephalosporin) have been tested for bioavailability in 12 healthy volunteers, using a triple crossover design. No significant differences were detectable between the bioequivalence of the three formulations in terms of area-under-curve and 24-h urinary excretion. However, one of the formulations (A) was absorbed significantly more rapidly from the site of injection, causing higher serum levels for up to 1.5 h after administration. A significantly greater urinary excretion was also found up to 8 h after administration of formulation A. All three formulations were well tolerated, and no side-effects or significant changes in laboratory tests were observed.
已采用三交叉设计，对12名健康志愿者测试了头孢尼西（一种新型长效头孢菌素）的三种不同肌肉注射制剂的生物利用度。就曲线下面积和24小时尿排泄量而言，三种制剂的生物等效性之间未发现显著差异。然而，其中一种制剂（A）从注射部位吸收明显更快，给药后长达1.5小时血清水平更高。在给予制剂A后长达8小时，也发现尿排泄量显著增加。所有三种制剂耐受性良好，未观察到副作用或实验室检查的显著变化。
