Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Germany.
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Germany; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Germany.
Mol Cell Endocrinol. 2021 Jul 1;531:111312. doi: 10.1016/j.mce.2021.111312. Epub 2021 May 4.
Excessive increased adipose tissue mass in obesity is associated with numerous co-morbid disorders including increased risk of type 2 diabetes, fatty liver disease, hypertension, dyslipidemia, cardiovascular diseases, dementia, airway disease and some cancers. The causal mechanisms explaining these associations are not fully understood. Adipose tissue is an active endocrine organ that secretes many adipokines, cytokines and releases metabolites. These biomolecules referred to as adipocytokines play a significant role in the regulation of whole-body energy homeostasis and metabolism by influencing and altering target tissues function. Understanding the mechanisms of adipocytokine actions represents a hot topic in obesity research. Among several secreted bioactive signalling molecules from adipose tissue and liver, retinol-binding protein 4 (RBP4) has been associated with systemic insulin resistance, dyslipidemia, type 2 diabetes and other metabolic diseases. Here, we aim to review and discuss the current knowledge on RBP4 with a focus on its role in the pathogenesis of obesity comorbid diseases.
肥胖症患者体内脂肪组织过度增加与许多合并症有关，包括 2 型糖尿病、脂肪肝疾病、高血压、血脂异常、心血管疾病、痴呆、气道疾病和某些癌症的风险增加。这些关联的因果机制尚不完全清楚。脂肪组织是一种活跃的内分泌器官，它会分泌许多脂肪因子、细胞因子并释放代谢物。这些被称为脂肪细胞因子的生物分子在调节全身能量平衡和代谢方面发挥着重要作用，它们通过影响和改变靶组织的功能来发挥作用。了解脂肪细胞因子作用的机制是肥胖研究的一个热门话题。在脂肪组织和肝脏分泌的几种生物活性信号分子中，视黄醇结合蛋白 4（RBP4）与全身胰岛素抵抗、血脂异常、2 型糖尿病和其他代谢性疾病有关。在这里，我们旨在综述和讨论 RBP4 的现有知识，重点介绍其在肥胖合并症发病机制中的作用。
