Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Biomed Pharmacother. 2021 Jul;139:111610. doi: 10.1016/j.biopha.2021.111610. Epub 2021 May 3.
Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation. Therefore, NSM and ASM have broad prospects in clinical treatments, especially in cancer, cardiovascular diseases (such as atherosclerosis), nervous system diseases (such as Alzheimer's disease), respiratory diseases (such as chronic obstructive pulmonary disease) and the phenotype of dwarfisms in adolescents, playing a complex regulatory role. This review focuses on the physiological functions of NSM and ASM and summarizes their roles in certain diseases and their potential applications in therapy.
鞘磷脂（SM）可通过中性鞘磷脂酶（NSM）和酸性鞘磷脂酶（ASM）转化为神经酰胺（Cer）。Cer 是脂质的第二信使，可调节细胞生长和凋亡。越来越多的证据表明，NSM 和 ASM 在许多过程中发挥着关键作用，如凋亡、免疫功能和炎症。因此，NSM 和 ASM 在临床治疗中具有广阔的前景，特别是在癌症、心血管疾病（如动脉粥样硬化）、神经系统疾病（如阿尔茨海默病）、呼吸系统疾病（如慢性阻塞性肺疾病）和青少年矮小症的表型中，发挥着复杂的调节作用。本文综述了 NSM 和 ASM 的生理功能，并总结了它们在某些疾病中的作用及其在治疗中的潜在应用。
