脑卒中后癫痫标志物研究进展。
Advances in the Development of Biomarkers for Poststroke Epilepsy.
机构信息
Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
出版信息
Biomed Res Int. 2021 Apr 17;2021:5567046. doi: 10.1155/2021/5567046. eCollection 2021.
Abstract
Stroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as interleukin-6 (IL-6), tumor necrosis factor- (TNF-), glutamate, and S100 calcium-binding protein B (S100B) in blood are associated with the occurrence of PSE. This review is aimed at summarizing the progress on potential biomarkers of PSE.
摘要
脑卒中是老年人获得性癫痫的主要病因。卒中后癫痫（PSE）不仅影响卒中后的功能恢复，而且带来相当大的社会后果。虽然皮质受累、出血性转化和卒中严重程度等一些因素与癫痫发作风险增加有关，但到目前为止，这一点仍存在争议。近年来，越来越多的研究关注 PSE 的潜在生物标志物，将其作为诊断和预测癫痫发作的工具。血液中的白细胞介素-6（IL-6）、肿瘤坏死因子-（TNF-）、谷氨酸和 S100 钙结合蛋白 B（S100B）等生物标志物与 PSE 的发生有关。本综述旨在总结 PSE 潜在生物标志物的研究进展。
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