Department of Medical Biology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Department of Cardiology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Adv Exp Med Biol. 2021;1347:183-195. doi: 10.1007/5584_2021_638.
The telomere length is shown to act as a biomarker, especially for biological aging and cardiovascular diseases, and it is also suggested that with this correlation, increased exposure to the oxidative stress accelerates the vascular aging process. Therefore, this study aims to understand the correlation between the plasma oxidative stress index (OSI) status and leukocyte telomere length (LTL) and cardiologic parameters between the ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) groups.
One hundred one newly diagnosed patients with STEMI (n = 55) and NSTEMI (n = 46) were included in the study, along with 100 healthy controls who matched the patients in terms of age and gender. Plasma total antioxidant status (TAS), total oxidant status (TOS), and LTL were measured.
When LTL, TAS, TOS, and OSI values were evaluated between the patient and control group, OSI (p = 0.000) and LTL (p = 0.05) values were statistically significant in the patient group compared to the control group. Evaluation was conducted to understand whether there is a difference between the STEMI and NSTEMI groups. The plasma OSI (p = 0.007) and LTL (p = 0.05) were found to be significantly lower in STEMI patients. However, LTL and OSI results were not statistically significant in NSTEMI patients.
This is the first study evaluating telomere length and oxidative stress in STEMI and NSTEMI patients in Turkey. Our results support the existence of short telomere length in STEMI patients. Future studies on telomere length and oxidative stress will support the importance of our findings.
端粒长度被证明是一种生物标志物，特别是对生物衰老和心血管疾病而言，并且还表明，随着这种相关性的存在，氧化应激的增加会加速血管衰老过程。因此，本研究旨在了解氧化应激指数（OSI）状态与白细胞端粒长度（LTL）以及ST 段抬高型心肌梗死（STEMI）和非 ST 段抬高型心肌梗死（NSTEMI）组之间的心脏参数之间的相关性。
本研究纳入了 101 例新诊断的 STEMI（n=55）和 NSTEMI（n=46）患者以及 100 名与患者年龄和性别相匹配的健康对照者。测量了血浆总抗氧化状态（TAS）、总氧化状态（TOS）和 LTL。
当比较患者组和对照组的 LTL、TAS、TOS 和 OSI 值时，OSI（p=0.000）和 LTL（p=0.05）值在患者组中与对照组相比具有统计学意义。评估了 STEMI 和 NSTEMI 组之间是否存在差异。发现 STEMI 患者的血浆 OSI（p=0.007）和 LTL（p=0.05）显著降低。然而，NSTEMI 患者的 LTL 和 OSI 结果没有统计学意义。
这是在土耳其首次评估 STEMI 和 NSTEMI 患者的端粒长度和氧化应激的研究。我们的研究结果支持 STEMI 患者存在短端粒长度的假说。关于端粒长度和氧化应激的未来研究将支持我们研究结果的重要性。
