Obstetrics and Gynecology Department, People's Hospital of Hekou District, Dongying, China.
J Pept Sci. 2021 Aug;27(8):e3326. doi: 10.1002/psc.3326. Epub 2021 May 6.
The goji berry is widely used as tonics; however, the antihuman cervical carcinoma effect and underlying mechanism of goji berry peptide remain to be elucidated. The cyclic peptides are appealing targets in antitumor agent development, and in current study, three novel goji berry cyclic peptides (GCPs) were isolated and amino acid sequence identified. Among them, GCP-1 (Cycle-(Trp-Glu-His-Thr)) inhibited proliferation and induced human cervical cancer (HeLa) cells apoptosis and blocked the HeLa cells in G0/G1 phase significantly. Furthermore, the GCP-1 also inhibited the cervical carcinoma growth in vivo. Moreover, GCP-1 suppressed the cyclin expression and activated the caspase cascade and poly(ADP-ribose) polymerase. Of note, GCP-1 may be a promising novel inhibitor of human cervical cancer.
枸杞被广泛用作补品；然而，枸杞肽的抗人宫颈癌作用及其机制仍有待阐明。环肽是抗肿瘤药物开发的有吸引力的靶标，在本研究中，分离并鉴定了三种新型枸杞环肽（GCPs）。其中，GCP-1（环-（色氨酸-谷氨酸-组氨酸-苏氨酸））显著抑制增殖并诱导人宫颈癌（HeLa）细胞凋亡，将 HeLa 细胞阻滞在 G0/G1 期。此外，GCP-1 还能抑制体内宫颈癌的生长。此外，GCP-1 抑制细胞周期蛋白的表达并激活半胱天冬酶级联和多聚（ADP-核糖）聚合酶。值得注意的是，GCP-1 可能是一种有前途的新型人宫颈癌抑制剂。
