Department of Hematology & Medical Laboratory Science, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, 7616911333, Iran.
Molecular Medicine Research Center, Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, 7718796755, Iran.
Future Oncol. 2021 Jul;17(21):2803-2816. doi: 10.2217/fon-2020-1072. Epub 2021 May 7.
An alarming increase in acute lymphoblastic leukemia cases among children and adults has attracted the attention of researchers to discover new therapeutic strategies with a better prognosis. In cancer cells, the DNA damage response (DDR) pathway elements have been recognized to protect tumor cells from various stresses and cause tumor progression; targeting these DDR members is an attractive strategy for treatment of cancers. The inhibition of the DDR pathway in cancer cells for the treatment of cancers has recently been introduced. Hence, effective treatment strategies are needed for this purpose. Chemotherapy in combination with radiotherapy is considered a potential therapeutic strategy for acute leukemia. This review aims to assess the synergistic effects of these inhibitors with irradiation for the treatment of leukemia.
儿童和成人中急性淋巴细胞白血病病例的惊人增长引起了研究人员的关注，以期发现具有更好预后的新治疗策略。在癌细胞中，DNA 损伤反应 (DDR) 通路元件已被确认为保护肿瘤细胞免受各种应激并导致肿瘤进展；靶向这些 DDR 成员是治疗癌症的一种有吸引力的策略。最近已经引入了抑制癌细胞 DDR 通路以治疗癌症。因此，为此目的需要有效的治疗策略。化疗联合放疗被认为是急性白血病的一种潜在治疗策略。本综述旨在评估这些抑制剂与辐射联合治疗白血病的协同作用。
