Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Department of Cardiology, Kayseri City Hospital, Kayseri, Turkey.
Perfusion. 2022 Sep;37(6):605-612. doi: 10.1177/02676591211014822. Epub 2021 May 7.
Recently, a new inflammatory and prognostic marker has emerged called as Systemic Immune Inflammation Index (SII). In the current study, we searched the relation between SII and Coronary Collateral Circulation (CCC) formation in stable Coronary Artery Disease (CAD).
MATERIALS & METHODS: 449 patients with stable CAD who underwent coronary angiography and documented coronary stenosis of 95% or more in at least one major coronary vessel were included in the study. The study patients were divided into two groups according to the Rentrop score as well CCC (Rentrop 2-3) and bad CCC (Rentrop 0-1). Blood samples for SII and other laboratory parameters were gathered from all the patients on admission. The SII score was formulized as platelet × neutrophil/lymphocyte counts.
Patients, who had developed bad CCC had a higher C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), platelets/lymphocyte ratio (PLR) and SII levels compared to those who had developed well CCC (p < 0.001, for all). Multivariate logistic regression analysis showed that high levels of SII was an independent predictor of bad CCC (OR: 1.005, 95% confidence interval (CI): 1.003-1.006, p < 0.001) together with dyslipidemia, high levels of CRP and NLR. In Receiver Operator Characteristic curve (ROC) analysis, the optimal cutoff value of SII to predict poor CCC was found to be 729.8, with 78.4% sensitivity and 74.6% specificity (area under ROC curve = 0.833 (95% CI: 0.777-0.889, p < 0.001).
We have demonstrated that SII, a novel cardiovascular risk marker, might be used as one of the independent predictors of CCC development.
最近出现了一种新的炎症和预后标志物，称为全身免疫炎症指数（SII）。本研究旨在探讨 SII 与稳定型冠状动脉疾病（CAD）患者冠状动脉侧支循环（CCC）形成的关系。
本研究共纳入 449 例接受冠状动脉造影且至少一条主要冠状动脉狭窄程度≥95%的稳定型 CAD 患者。根据Rentrop 评分和 CCC（Rentrop 2-3 级和差 CCC（Rentrop 0-1 级）将患者分为两组。所有患者入院时均采集 SII 和其他实验室参数的血样。SII 评分公式为血小板×中性粒细胞/淋巴细胞计数。
与形成良好 CCC 的患者相比，形成差 CCC 的患者的 C 反应蛋白（CRP）、中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）和 SII 水平更高（均 P<0.001）。多变量 logistic 回归分析显示，SII 水平升高是形成差 CCC 的独立预测因子（OR：1.005，95%置信区间（CI）：1.003-1.006，P<0.001），同时还与血脂异常、高 CRP 和 NLR 水平相关。在受试者工作特征曲线（ROC）分析中，SII 预测差 CCC 的最佳截断值为 729.8，敏感性为 78.4%，特异性为 74.6%（ROC 曲线下面积=0.833（95%CI：0.777-0.889，P<0.001）。
我们的研究表明，SII 作为一种新的心血管风险标志物，可能成为 CCC 发展的独立预测因子之一。
