The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Org Biomol Chem. 2021 May 26;19(20):4492-4496. doi: 10.1039/d1ob00487e.
A nickel-catalyzed asymmetric Suzuki-Miyaura cross-coupling of racemic 3-bromo-phthalides and arylboronic acids was realized for the synthesis of diverse chiral 3-aryl-phthalides in moderate to excellent reaction yields. The reaction proceeded in a stereoconvergent manner and high enantioselectivities were observed for most examined examples. A number of functional groups like aldehyde, ester and bromide were well tolerated. Heteroaromatic boronic acids were also competent coupling partners in this reaction.
镍催化的外消旋 3-溴邻苯二甲酸酐与芳基硼酸的不对称铃木-宫浦交叉偶联反应实现了多种手性 3-芳基邻苯二甲酸酐的中等至优异的反应收率的合成。该反应以立体协同的方式进行，大多数情况下观察到高对映选择性。许多官能团，如醛、酯和溴化物都能很好地耐受。杂芳基硼酸也是该反应的有效偶联试剂。
