Pannuti F, Coppi G, Borella F, Martoni A, Urbano L, Melotti B
Divisione di Oncologia, Ospedale S. Orsola, Bologna, Italy.
Chemioterapia. 1988 Apr;7(2):113-6.
The pharmacokinetics of PTT-119, a new alkylating agent, was studied in 8 advanced cancer patients. PTT-119 disappeared rapidly from plasma after administration at a dose of 3 mg/kg by i.v. bolus injection. The HPLC method shows plasma levels of m-bis (dichloroethyl)amino-phenyl-L-alanine which is the major metabolite of PPT-119. Elimination of the drug from plasma can be described by a one-compartment model. Mean values of 77.8 min for the half-life, 510.8 ml/min for the total plasma clearance and 0.69 l/kg for the volume of distribution were found.
对8例晚期癌症患者研究了新型烷化剂PTT - 119的药代动力学。通过静脉推注以3mg/kg的剂量给药后，PTT - 119迅速从血浆中消失。HPLC法显示了间双（二氯乙基）氨基苯基-L-丙氨酸的血浆水平，其为PPT - 119的主要代谢产物。药物从血浆中的消除可用单室模型描述。半衰期的平均值为77.8分钟，总血浆清除率为510.8ml/min，分布容积为0.69l/kg。
