Iushchuk N D, Kichik E I, Sergeev V V, Godovannyĭ B A, Tumanov F A
Zh Mikrobiol Epidemiol Immunobiol. 1977 Nov(11):90-4.
Comparative study of various methods of treatment was carried out on 777 patients suffering from acute dysentery with a bacteriologically confirmed diagnosis. To assess the therapeutic efficacy, along with consideration of clinical signs of the disease, immunoglobulin level was examined in the blood and coprofiltrates; also the state of reparative processes in the mucosa was appreciated by the histological examination of the biopsy material. Results of the work carried out indicated the inexpediency of the treatment of this disease with a combination of levomycetin and phthalazol. The use of live streptomycin-dependent dysentery vaccine was indicated in protracted torpid dysentery and was of no avail in acute form of the disease. A good therapeutic effect was observed with the application of pathogenetic therapy alone.
对777例经细菌学确诊的急性痢疾患者进行了各种治疗方法的比较研究。为评估治疗效果,除考虑疾病的临床症状外,还检测了血液和粪便滤液中的免疫球蛋白水平;通过活检材料的组织学检查评估黏膜修复过程的状态。所开展工作的结果表明,用氯霉素和酞磺胺噻唑联合治疗这种疾病是不合适的。在迁延性迟缓型痢疾中使用活的链霉素依赖型痢疾疫苗,而在该病的急性形式中则无效。单独应用病因疗法观察到了良好的治疗效果。