鸡骨常山根中的异黄烷醌及其抗增殖和抗炎作用。

Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects.

机构信息

Biochemistry Department, Babcock University Ilishan-Remo, Ikeja, PMB 21244, Nigeria; Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan; Biology Department, Adventist University of West Africa, Monrovia, Liberia.

HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.

出版信息

Phytochemistry. 2021 Jul;187:112743. doi: 10.1016/j.phytochem.2021.112743. Epub 2021 May 4.

DOI:10.1016/j.phytochem.2021.112743

PMID:33962136

Abstract

Phytochemical studies on the root of Abrus precatorius Linn. (Fabaceae), leads towards the identification of four undescribed (abruquinones M, N, O, and P), and seven known abruquinones, (abruquinones A, E, B, F, I, D, and G). Spectroscopic analyses (1D, and 2D NMR, HRESI-MS) were used in elucidating structures of the all compounds. Evaluation of anticancer activities of the isolated isoflavanquinones revealed that abruquinones M, and N showed cytotoxicity against oral CAL-27 (IC values 6.48 and 5.26 μM, respectively), and colon (Caco-) cell lines (IC values 15.79 and 10.33 μM, respectively). Abruquinone M also inhibited the growth of lung cancer cells (NCI-H460) with IC of 31.33 μM. The isolated isoflavanquiones also showed potent anti-inflammatory potential through phagocyte oxidative burst and pro-inflammatory cytokine TNF-α inhibition in vitro. These findings suggest isoflavanquinones from A. precatorius roots as candidates for further research in cancer treatment.

摘要

植物化学研究表明，鸡屎藤（豆科）的根部含有四种未被描述的（abruquinones M、N、O 和 P）和七种已知的 abruquinones（abruquinones A、E、B、F、I、D 和 G）。光谱分析（1D 和 2D NMR、HRESI-MS）用于阐明所有化合物的结构。对分离出的异黄酮醌类化合物的抗癌活性进行评估，结果表明 abruquinones M 和 N 对口腔 CAL-27（IC 值分别为 6.48 和 5.26 μM）和结肠（Caco-）细胞系具有细胞毒性（IC 值分别为 15.79 和 10.33 μM）。Abruquinone M 还抑制肺癌细胞（NCI-H460）的生长，IC 值为 31.33 μM。分离出的异黄酮醌类化合物还具有通过吞噬细胞氧化爆发和抑制促炎细胞因子 TNF-α 的体外抗炎潜力。这些发现表明鸡屎藤根部的异黄酮醌类化合物是癌症治疗进一步研究的候选药物。