Applied Physiology & Kinesiology, College of Health and Human Performance, University of Florida, 1864 Stadium Road, Gainesville, FL 32611, USA.
Applied Physiology & Kinesiology, College of Health and Human Performance, University of Florida, 1864 Stadium Road, Gainesville, FL 32611, USA.
Semin Cell Dev Biol. 2021 Nov;119:11-22. doi: 10.1016/j.semcdb.2021.04.018. Epub 2021 May 5.
Muscle regeneration requires the coordination of several factors to mobilize satellite cells and macrophages, remodel the extracellular matrix surrounding muscle fibers, and repair existing and/or form new muscle fibers. In this review, we focus on insulin-like growth factor I and the matrix metalloproteinases, which are secreted proteins that act on cells and the matrix to resolve damage. While their actions appear independent, their interactions occur at the transcriptional and post-translational levels to promote feed-forward activation of each other. Together, these proteins assist at virtually every step of the repair process, and contribute significantly to muscle regenerative capacity.
肌肉再生需要协调多个因素来动员卫星细胞和巨噬细胞、重塑围绕肌肉纤维的细胞外基质，并修复现有的和/或形成新的肌肉纤维。在这篇综述中，我们重点介绍胰岛素样生长因子 I 和基质金属蛋白酶，它们是作用于细胞和基质以解决损伤的分泌蛋白。虽然它们的作用似乎是独立的，但它们在转录和翻译后水平上相互作用，以促进彼此的前馈激活。这些蛋白质共同协助修复过程的几乎每一个步骤，并对肌肉再生能力做出重大贡献。
