Carmeli Eli, Moas Miri, Reznick Abraham Z, Coleman Raymond
Department of Physical Therapy, Sackler Faculty of Medicine, Stanley Steyer School of Health Professions, Tel Aviv University, Ramat Aviv 69978, Israel.
Muscle Nerve. 2004 Feb;29(2):191-7. doi: 10.1002/mus.10529.
Matrix metalloproteinases (MMPs) are a family of zinc- dependent proteolytic enzymes that function mainly in the extracellular matrix, where they contribute to the development, functioning, and pathology of a wide range of tissues. This mini-review describes the MMPs and tissue inhibitors of MMPs (TIMPs) in skeletal muscle, and considers their involvement in muscle development, ischemia, myonecrosis, angiogenesis, denervation, exercise-induced injuries, disuse atrophy, muscle repair and regeneration, and inflammatory myopathies and dystrophies. Despite the very limited information currently available on MMPs and their inhibitors in skeletal muscle, it is becoming increasingly clear that they have important physiological functions in maintenance of the integrity and homeostasis of muscle fibers and of the extracellular matrix. Understanding the roles of MMPs and TIMPs may lead to the development of new drug-related treatments for various muscle disorders based on suppression or upregulation of their expression.
基质金属蛋白酶（MMPs）是一类锌依赖性蛋白水解酶，主要在细胞外基质中发挥作用，在多种组织的发育、功能及病理过程中起作用。本综述介绍了骨骼肌中的基质金属蛋白酶及其组织抑制剂（TIMPs），并探讨了它们在肌肉发育、缺血、肌坏死、血管生成、去神经支配、运动性损伤、废用性萎缩、肌肉修复与再生以及炎性肌病和肌营养不良中的作用。尽管目前关于骨骼肌中基质金属蛋白酶及其抑制剂的信息非常有限，但越来越清楚的是，它们在维持肌纤维和细胞外基质的完整性及稳态方面具有重要的生理功能。了解基质金属蛋白酶和组织抑制剂的作用可能会基于对其表达的抑制或上调，开发出针对各种肌肉疾病的新型药物相关治疗方法。
