Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA.
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
MAGMA. 2021 Oct;34(5):649-658. doi: 10.1007/s10334-021-00927-y. Epub 2021 May 8.
To evaluate the potential clinical benefit of the superior spatial resolution of 3D prototype thin-slab stack-of-stars (tsSOS) quiescent-interval slice-selective (QISS) MRA over standard 2D-QISS MRA for the detection peripheral artery disease (PAD), using computed tomography angiography (CTA) as reference.
Twenty-three patients (70 ± 8 years, 18 men) with PAD who had previously undergone run-off CTA were prospectively enrolled. Patients underwent non-contrast MRA using 2D-QISS and tsSOS-QISS at 1.5 T. Eighteen arterial segments were evaluated for subjective and objective image quality (normalized signal-to-noise, nSNR), vessel sharpness, and area under the curve (AUC) for > 50% stenosis detection.
Overall subjective image quality ratings for the entire run-off were not different between tsSOS-QISS and 2D-QISS (3 [3; 4] vs 4 [3; 4], respectively; P = 0.813). Sharpness of primary branch vessels demonstrated improved image quality using tsSOS-QISS compared with 2D-QISS (4 [3; 4] vs 3 [2; 3], P = 0.008). Objective image quality measures were not different between 2D-QISS and tsSOS-QISS (nSNR 5.0 ± 1.9 vs 4.2 ± 1.8; P = 0.132). AUCs for significant stenosis detection by tsSOS-QISS and 2D-QISS were 0.877 and 0.856, respectively (P = 0.336).
The prototype 3D tsSOS-QISS technique provides similar accuracy in patients with PAD to a standard commercially available 2D-QISS technique, indicating that the use of relatively thick slices does not limit the diagnostic performance of 2D-QISS. However, subjective image quality for branch vessel depiction is improved using the 3D approach.
利用计算机断层血管造影（CTA）作为参考，评估三维原型薄切片堆积星状（tsSOS）静息间期切片选择（QISS）磁共振血管成像（MRA）相对于标准 2D-QISS MRA 在检测外周动脉疾病（PAD）方面的优势，即其具有更高的空间分辨率。
前瞻性纳入 23 例 PAD 患者（70±8 岁，18 名男性），这些患者之前均进行过静脉期 CTA 检查。所有患者在 1.5 T 磁共振仪上接受了 2D-QISS 和 tsSOS-QISS 非对比 MRA 检查。对 18 个动脉节段进行主观和客观图像质量（归一化信噪比，nSNR）、血管锐利度和>50%狭窄检测的曲线下面积（AUC）评估。
整个静脉期的总体主观图像质量评分在 tsSOS-QISS 和 2D-QISS 之间没有差异（分别为 3[3;4]和 4[3;4]；P=0.813）。与 2D-QISS 相比，使用 tsSOS-QISS 可改善主支血管的锐度（4[3;4]与 3[2;3]；P=0.008）。2D-QISS 和 tsSOS-QISS 之间的客观图像质量指标没有差异（nSNR 分别为 5.0±1.9 和 4.2±1.8；P=0.132）。tsSOS-QISS 和 2D-QISS 检测显著狭窄的 AUC 分别为 0.877 和 0.856（P=0.336）。
原型 3D tsSOS-QISS 技术在外周动脉疾病患者中提供了与标准商用 2D-QISS 技术相似的准确性，这表明使用相对较厚的切片不会限制 2D-QISS 的诊断性能。然而，使用 3D 方法可以改善分支血管的显示的主观图像质量。
