STS 557对帽猴（食蟹猴）精液及精子功能的影响——初步报告

Effects of STS 557 on semen and sperm functions in bonnet monkey (Macaca radiata)--a preliminary report.

作者信息

Majumdar S S, Sharma R K, Das R P

机构信息

Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, New Delhi, India.

出版信息

Contraception. 1988 Jun;37(6):631-41. doi: 10.1016/0010-7824(88)90009-1.

DOI:10.1016/0010-7824(88)90009-1

PMID:3396360

Abstract

Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm motility was reduced from the 3rd week of treatment. Complete recovery was observed by the 14th week after withdrawal of treatment. STS 557 may have the potentiality to be used as a chemical contraceptive in the male.

摘要

以每日12毫克/只猴子的剂量对猴子进行8周的肌肉注射STS 557（17α-氰甲基-17β-羟基-雌甾-4,9(10)-二烯-3-酮），在开始治疗的第9周时导致严重少精子症直至完全无精子症，同时睾酮血清水平下降。治疗第3周起精子活力降低。停药后第14周观察到完全恢复。STS 557可能有潜力用作男性化学避孕药。