Department of Collective Health, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Int J Cancer. 2021 Sep 1;149(5):1044-1053. doi: 10.1002/ijc.33673. Epub 2021 May 17.
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. The etiology of OS is largely unknown but may be informed by comparisons of incidence and trends between geographic regions. Using the Cancer Incidence in Five Continents (CI5) data from 1988 to 2012, we present OS age-standardized incidence rates (ASRs; cases/million) and average annual percent change (AAPC) and 95% confidence interval (CI) by geographic region among the age groups 0-9, 10-19, 20-29, 30-59, 60-79, 0-79. Among the 10-19 age group, we also used the most recent data (2008-2012) to present the ASRs for each country. We observed little variation in OS incidence between geographic regions in 2008-2012 across all age groups. Overall, the ASR for 0-79 ranged from 2 cases per million in Southern Asia to 4.2 in Sub-Saharan Africa. A bimodal distribution in incidence was observed with peaks in the 10-19 and 60-79 age groups across all regions over time. Overall, OS incidence was relatively stable across 1988-2012 with the only statistically significant increases in the 0-79 age group observed in Eastern Asia (AAPC: 1.8; 95% CI: 0.6, 1.9) and Sub-Saharan Africa (AAPC: 3.1; 95% CI: 0.5, 5.8). The small variation in incidence between regions and the stability in incidence over time suggests that OS carcinogenesis is not influenced by environmental or time-varying exposures.
骨肉瘤（OS）是儿童和青少年中最常见的原发性骨肿瘤。OS 的病因在很大程度上尚不清楚，但可以通过比较地理区域之间的发病率和趋势来了解。利用 1988 年至 2012 年的《五大洲癌症发病率》（CI5）数据，我们根据年龄组（0-9 岁、10-19 岁、20-29 岁、30-59 岁、60-79 岁和 0-79 岁），呈现了地理区域间 OS 年龄标准化发病率（ASR；每百万病例）和平均年百分比变化（AAPC）及 95%置信区间（CI）。在 10-19 岁年龄组中，我们还使用最新数据（2008-2012 年）呈现了每个国家的 ASR。我们观察到，在 2008-2012 年期间，所有年龄组中，地理区域间 OS 发病率差异不大。总体而言，0-79 岁的 ASR 范围从南亚的每百万 2 例到撒哈拉以南非洲的每百万 4.2 例。随着时间的推移，所有地区的发病率均呈现双峰分布，高峰出现在 10-19 岁和 60-79 岁年龄组。总体而言，1988-2012 年期间，OS 发病率相对稳定，仅在东亚（AAPC：1.8；95%CI：0.6，1.9）和撒哈拉以南非洲（AAPC：3.1；95%CI：0.5，5.8）观察到 0-79 岁年龄组的发病率有统计学意义的增加。区域间发病率的微小差异和随时间的发病率稳定性表明，OS 的致癌作用不受环境或时变暴露的影响。
