CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA.
Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.
J Clin Hypertens (Greenwich). 2021 Jun;23(6):1229-1238. doi: 10.1111/jch.14244. Epub 2021 May 8.
Although the role of magnesium in blood pressure has been well studied among hypertensive patients, no study has explored the role of magnesium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum magnesium levels between hypertensive crises patients and matched controls (age-, sex-, race-, and diabetes-matched) in a 1:1 random match. This study is a single-center, retrospective, chart review, case-control study of patients with hypertensive crises (case group) and patients without hypertensive crises (control group). Patients were included in the case group if they were 18 years of age or older with hypertensive crises and have a documented magnesium level. The control group patients were required to be 18 years of age or older, have no diagnosis of hypertensive crises, and have a documented magnesium level. The primary outcome of the study was to compare the mean serum magnesium in patients with hypertensive crises versus patients without hypertensive crises. Three hundred and fifty-eight patients were included in the study: 179 patients in both the case group and control group. The primary outcome results showed that serum magnesium concentration was not significantly different between the case group (1.89 ± 0.29 mg/dl) and control group (1.90 ± 0.31 mg/dl) (p = .787). This study found no significant difference in serum magnesium levels in patients with hypertensive crises compared to a random matched control group. Larger observational or experimental studies may be useful to evaluate the effect of magnesium on blood pressure in hypertensive crises.
虽然镁在高血压患者的血压中的作用已经得到了很好的研究，但没有研究探讨镁在高血压危象中的作用。本研究的主要目的是评估高血压危象患者与匹配对照（年龄、性别、种族和糖尿病匹配）之间血清镁水平的差异，采用 1:1 随机匹配。这是一项单中心、回顾性、图表审查、病例对照研究，纳入了高血压危象患者（病例组）和无高血压危象患者（对照组）。如果患者年龄在 18 岁或以上，患有高血压危象并有记录的镁水平，则将其纳入病例组。对照组患者需要年龄在 18 岁或以上，没有高血压危象的诊断，并且有记录的镁水平。研究的主要结局是比较高血压危象患者与无高血压危象患者的平均血清镁水平。本研究共纳入 358 例患者：病例组和对照组各 179 例。主要结局结果显示，病例组（1.89±0.29mg/dl）和对照组（1.90±0.31mg/dl）之间血清镁浓度无显著差异（p=0.787）。与随机匹配对照组相比，高血压危象患者的血清镁水平没有显著差异。更大规模的观察性或实验性研究可能有助于评估镁对高血压危象中血压的影响。
