Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China; College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
Colloids Surf B Biointerfaces. 2021 Aug;204:111803. doi: 10.1016/j.colsurfb.2021.111803. Epub 2021 Apr 29.
The hypoxic tumor environment prevents the generation of reactive oxygen species (ROS), reducing the therapeutic efficiency. We construct oleylamine (OA) coated CaO/FeO nanocomposites to realize oxygen-independent generation of ROS and high efficient treatment of cancer. In the tumor site, CaO reacts with water to generate HO, which can be catalized by Fe that is produced by FeO, to form highly toxic hydroxyl radicals (∙OH). To inhibit the premature reaction, CaO/FeO nanoparticles were coated with pH sensitive OA. The nanocomposites exhibited remarkable tumor growth inhibition ability and favorable biocompatibility, holding a great potential for hypoxic tumor therapy.
缺氧的肿瘤微环境会阻止活性氧（ROS）的产生，从而降低治疗效率。我们构建了油胺（OA）包覆的 CaO/FeO 纳米复合材料，以实现不依赖于氧的 ROS 生成和高效的癌症治疗。在肿瘤部位，CaO 与水反应生成 HO，HO 可被由 FeO 产生的 Fe 催化生成高毒性的羟基自由基（∙OH）。为了抑制过早反应，CaO/FeO 纳米颗粒被 pH 敏感的 OA 包覆。该纳米复合材料表现出显著的肿瘤生长抑制能力和良好的生物相容性，在缺氧肿瘤治疗方面具有巨大的应用潜力。
