Ogrinc Nina, Saudemont Philippe, Takats Zoltan, Salzet Michel, Fournier Isabelle
University of Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France.
University of Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France; Institut Universitaire de France (IUF), Paris, France.
Trends Mol Med. 2021 Jun;27(6):602-615. doi: 10.1016/j.molmed.2021.04.001. Epub 2021 May 5.
In vivo cancer margin delineation during surgery remains a major challenge. Despite the availability of several image guidance techniques and intraoperative assessment, clear surgical margins and debulking efficiency remain scarce. For this reason, there is particular interest in developing rapid intraoperative tools with high sensitivity and specificity to help guide cancer surgery in vivo. Recently, several emerging technologies including intraoperative mass spectrometry have paved the way for molecular guidance in a clinical setting. We evaluate these techniques and assess their relevance for intraoperative surgical guidance and how they can transform the future of molecular cancer surgery, diagnostics, patient management and care.
手术过程中在体癌症切缘的界定仍然是一项重大挑战。尽管有多种图像引导技术和术中评估手段，但清晰的手术切缘和肿瘤减灭效率仍然不足。因此，开发具有高灵敏度和特异性的快速术中工具以帮助在体指导癌症手术备受关注。最近，包括术中质谱分析在内的几种新兴技术为临床环境中的分子引导铺平了道路。我们评估这些技术，并评估它们与术中手术引导的相关性，以及它们如何改变分子癌症手术、诊断、患者管理和护理的未来。
