Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, USA; Indiana Center for Musculoskeletal Health, USA.
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Bone. 2021 Sep;150:115994. doi: 10.1016/j.bone.2021.115994. Epub 2021 May 7.
MicroRNAs, identified in the early 1990s, are believed to regulate approximately 30% of the human genome. The role of microRNA in bone cells was first reported in 2007 in a manuscript showing that microRNA-223 is essential for osteoclast differentiation in vitro, and a few studies reported a role of microRNAs in osteoblasts the same year. The first report of microRNA actions in osteocytes was published in 2010, in which it was demonstrated that the microRNA cluster 23a27a24-2 regulates osteocyte differentiation. Since then, few studies have described the role of these 18-25-nucleotide non-coding RNAs on osteocyte biology, reporting osteocytes both as producers and as targets of the actions of microRNAs. We review here the current knowledge on the effects of microRNAs on osteocyte biology.
微 RNA 于 20 世纪 90 年代初被发现，据信可调控人类基因组的约 30%。2007 年的一篇论文首次报道了微 RNA 在骨细胞中的作用，表明微 RNA-223 对体外破骨细胞分化至关重要，同年的少数研究报告了微 RNA 在成骨细胞中的作用。2010 年发表了第一篇关于骨细胞中微 RNA 作用的报告，表明微 RNA 簇 23a27a24-2 调节骨细胞分化。从那时起，很少有研究描述这些 18-25 个核苷酸的非编码 RNA 对骨细胞生物学的作用，报告称骨细胞既是微 RNA 作用的产生者，也是其作用的靶点。我们在此综述了目前关于微 RNA 对骨细胞生物学影响的认识。
