Department of Psychiatry, National Taiwan University Hospital Hsin-Chu Branch, No.25, Lane 442, Sec.1, Jingguo Rd., Hsinchu City 300, Taiwan.
Department of Psychiatry, National Taiwan University Hospital, No.7 Chung San South Road, Taipei 10002, Taiwan.
Gen Hosp Psychiatry. 2021 Jul-Aug;71:82-87. doi: 10.1016/j.genhosppsych.2021.04.009. Epub 2021 May 1.
Premenstrual dysphoric symptoms (PMDS) commonly co-occurred with mood disorders and correlated with suicide experiences in women. This study aims to examine the associations between PMDS and lifetime suicide experiences in patients with mood disorders.
Participants were recruited from outpatient settings of two medical centers and one psychiatric hospital in Taiwan. Women aged 18-65 in non-acute state of major depressive disorder or bipolar affective disorder were recruited. PMDS and lifetime suicide experiences were defined by the Schedule for Affective Disorder and Schizophrenia-Lifetime. Lifetime suicide experiences were defined as no suicide experience, suicide plans only and suicide attempts.
A total of 383 women participated in this study (54.8% of them were diagnosed with major depressive disorder), and 13.8% were diagnosed with PMDS. The prevalence of patients with lifetime suicide plans only and lifetime suicide attempts were 15.9% and 39.7%, respectively. In the univariate analysis, PMDS was correlated with lifetime suicide experience. After controlling for covariates, PMDS was a risk indicator for lifetime suicide attempts (OR: 3.46, 95% CI: 1.43-8.38) but not for suicide plans only (OR: 0.93, 95% CI: 0.28-3.11).
PMDS correlated with lifetime suicide experiences in women with non-acute mood disorders. In particular, PMDS exhibited as an independent correlate for lifetime suicide attempts.
经前烦躁障碍（PMDS）常与心境障碍共病，并与女性的自杀经历相关。本研究旨在探讨心境障碍患者中 PMDS 与终生自杀经历之间的关系。
参与者来自台湾两家医疗中心和一家精神病院的门诊。招募年龄在 18-65 岁、处于非急性期的单相重性抑郁障碍或双相情感障碍的女性。PMDS 和终生自杀经历由情感障碍和精神分裂症的日程表来定义。终生自杀经历定义为无自杀经历、仅有自杀计划和自杀尝试。
共有 383 名女性参与了本研究（其中 54.8%被诊断为重性抑郁障碍），13.8%被诊断为 PMDS。有终生自杀计划和自杀尝试的患者比例分别为 15.9%和 39.7%。在单因素分析中，PMDS 与终生自杀经历相关。在控制了混杂因素后，PMDS 是终生自杀尝试的危险因素（OR：3.46，95% CI：1.43-8.38），但不是仅有自杀计划的危险因素（OR：0.93，95% CI：0.28-3.11）。
PMDS 与非急性期心境障碍女性的终生自杀经历相关。特别是，PMDS 是终生自杀尝试的独立相关因素。
