Division of Urology, Department of Surgery, University Health Network, University of Toronto, Canada.
Joint Department of Medical Imaging, University Health Network, University of Toronto, Canada.
Clin Imaging. 2021 Aug;76:217-221. doi: 10.1016/j.clinimag.2021.04.014. Epub 2021 Apr 28.
While focal therapy (FT) is increasingly endorsed for treating localized prostate cancer in the appropriately selected patient, management of recurrences following FT is not well-established in the literature. This case series describes three patients who received high-intensity focal ultrasound (HIFU) for primary treatment followed by focal laser interstitial thermal therapy (FLTT) for salvage therapy treated in the context of an ongoing clinical trial. Evaluation of these reported patients demonstrates that FLTT is feasible in the salvage setting with promising short-term oncologic outcomes and with the potential to preserve functional outcomes. Repeat focal therapy for previous failures is feasible however, it requires sophisticated imaging modalities for the accurate identification of recurrence and treatment of the tumor.
虽然对于适当选择的患者，局灶性治疗（FT）越来越被认可用于治疗局限性前列腺癌，但在文献中尚未确定 FT 后复发的治疗方法。本病例系列描述了 3 名患者，他们在一项正在进行的临床试验中接受高强度聚焦超声（HIFU）作为主要治疗方法，随后接受局灶性激光间质热疗（FLTT）进行挽救性治疗。对这些报告患者的评估表明，FLTT 在挽救治疗中是可行的，具有有前途的短期肿瘤学结果，并有可能保留功能结果。对于先前失败的患者进行重复局灶性治疗是可行的，但是需要复杂的成像方式来准确识别复发并治疗肿瘤。
