Mikkelsen E O, Nyborg N C, Jensen K T, Boeck V
Institute of Pharmacology, University of Aarhus, Denmark.
Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8. doi: 10.1016/0014-2999(88)90053-2.
The relaxant effect of irindalone [+)-(1R, 3.S)-1-[2-[4-[3-(p-fluorophenyl)-1-indanyl]-1-piperazinyl] ethyl]2-imidazolidinone) and ketanserin was studies on active tension in isolated rat thoracic aorta. Irindalone and ketanserin caused a concentration-related inhibition of serotonin-induced contractions and shifted the serotonin curve to the right. Irindalone was more potent in inhibiting the serotonin-induced contractions and ketanserin was. The slopes of the Schild plots for the two substances were slightly, but not significantly, different from each other. This indicates that irindalone had a more pronounced serotonin antagonistic effect than ketanserin.
