弹性成像在鉴别诊断睾丸良恶性病变中的应用：一项荟萃分析。

Elastography for the differential diagnosis of malignant versus benign testicular lesions: a meta-analysis.

作者信息

Lin Ziwei, Lin Rui, Wu Huaiyu, Wu Linghu, Zeng Jieying, Xu Jinfeng, Dong Fajin

机构信息

Department of Ultrasound, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

Department of Ultrasound, Shenzhen Luohu Maternity and Child Healthcare Hospital, Shenzhen, China.

出版信息

Ultrasonography. 2021 Oct;40(4):465-473. doi: 10.14366/usg.20191. Epub 2021 Feb 2.

DOI:10.14366/usg.20191

PMID:33966362

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8446503/

Abstract

PURPOSE

The aim of this study was to evaluate the value of elastography in the differential diagnosis of benign versus malignant testicular lesions.

METHODS

The PubMed, Cochrane Library, and Embase databases were searched for relevant studies. The diagnostic accuracy of elastography was evaluated using pooled sensitivity, specificity, likelihood ratio, post-test probability, diagnostic odds ratio, and by summarizing the area under the hierarchical summary receiver operating characteristic (HSROC) curve.

RESULTS

Seven studies with 568 lesions were included. The pooled sensitivity and specificity were 87% (95% confidence interval [CI], 81% to 92%) and 81% (95% CI, 65% to 90%), respectively. The pooled estimates of the positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 4.48 (95% CI, 2.37 to 8.47), 0.16 (95% CI, 0.10 to 0.25), and 28.11 (95% CI, 11.39 to 69.36), respectively. The area under the HSROC curve was 90% (95% CI, 88% to 93%).

CONCLUSION

Elastography is useful for assessing the stiffness of testicular lesions and for differentiating benign from malignant lesions. Elastography can be an effective supplement to conventional ultrasonography.

摘要

目的

本研究旨在评估弹性成像在鉴别睾丸良性与恶性病变中的价值。

方法

检索PubMed、Cochrane图书馆和Embase数据库中的相关研究。使用合并敏感度、特异度、似然比、验后概率、诊断比值比，并通过总结分层汇总接受者操作特征（HSROC）曲线下面积来评估弹性成像的诊断准确性。

结果

纳入7项研究，共568个病变。合并敏感度和特异度分别为87%（95%置信区间[CI]，81%至92%）和81%（95%CI，65%至90%）。阳性似然比、阴性似然比和诊断比值比的合并估计值分别为4.48（95%CI，2.37至8.47）、0.16（95%CI，0.10至0.25）和28.11（95%CI，11.39至69.36）。HSROC曲线下面积为90%（95%CI，88%至93%）。