Department of Geriatrics, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Ann Palliat Med. 2021 Apr;10(4):4878-4881. doi: 10.21037/apm-21-853.
Alzheimer's disease (AD) is a severe neurodegenerative disease which impacts the quality of life in elderly patients and imposes a significant burden to families and caregivers. The prolonged life expectancy and rapidly increasing world population significantly increased the morbidity. Although it has been widely reported that the aggregation of Beta amyloid and neurofilaments is the most significant pathological change. Currently, there is no effective drug therapy for AD, and the potential risks of pharmacotherapy remain concerns. This article reviews the recent research on Doll therapy (DT), a widely used non-drug therapy on AD patients, especially its clinical effectiveness and precautions in treating AD, with an attempt to further alleviate the mental symptoms and improve the health status of AD patients. Thus, nonpharmacological treatments of AD have become an area of intense research interest in recent years. DT is a person-centered therapy that can improve both the mental and cognitive status and the quality of life in AD patients. Although there remains ethical controversy about the DT on AD patients, its positive effect has been proved. Moreover, a standards manual is required to stipulate the range of application, the time course for treatment and withdraw the toy from the patients.
阿尔茨海默病（AD）是一种严重的神经退行性疾病，会影响老年患者的生活质量，并给家庭和护理人员带来巨大负担。预期寿命的延长和世界人口的快速增长显著增加了发病率。尽管已经广泛报道β淀粉样蛋白和神经丝的聚集是最显著的病理变化。目前，AD 尚无有效的药物治疗方法，药物治疗的潜在风险仍然令人关注。本文综述了玩偶疗法（DT）的最新研究进展，DT 是一种广泛应用于 AD 患者的非药物治疗方法，特别是其在治疗 AD 中的临床疗效和注意事项，旨在进一步缓解 AD 患者的精神症状，改善其健康状况。因此，近年来，AD 的非药物治疗已成为研究热点。DT 是一种以人为中心的疗法，可以改善 AD 患者的精神和认知状态以及生活质量。尽管关于 AD 患者的 DT 仍存在伦理争议，但已证明其具有积极作用。此外，需要制定标准手册来规定应用范围、治疗时间过程，并从患者手中收回玩具。
