An optimized preparation of nanofiber hydrogels derived from natural carbohydrate polymers and their drug release capacity under different pH surroundings.

Cellulose and chitin, as the two important natural carbohydrate polymers, have possibility to disassemble to biomass derived polysaccharide nanofibers. The 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) oxidized nanocellulose and nanochitin based hydrogel was fabricated via acid gas phase coagulation. It was observed that hydrogels began to form when the pH was lower than 3. When 0.1 mL of acetic acid coagulation bath was provided, 10 h were enough to form sufficient physical crosslinking. Moreover, the release time of amygdalin loaded in the hydrogel could be more than 60 h with a release amount of 80 % due to the uniform network and water-bearing structure. Meanwhile, the release capacity of hydrogels showed diversity at different pH surroundings, which was attributed to the existence of carboxyl groups on the oxidized nanofiber. The results suggested the possible application of the produced nanofiber hydrogels in some specific areas, such as drug delivery, wound dressing, and food packaging.