University of Queensland, School of Public Health, Faculty of Medicine, Brisbane, Queensland, Australia.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
J Alzheimers Dis. 2021;81(4):1589-1599. doi: 10.3233/JAD-201175.
The prevalence of dementia is generally reported to be higher among Indigenous peoples.
The rates and coding of dementia mortality were compared between Indigenous and non-Indigenous Australians.
De-identified individual records on causes of death for all people aged 40 years or more who died in Australia between 2006 and 2014 (n = 1,233,084) were used. There were 185,237 records with International Classification of Diseases, Tenth Revision, codes for dementia (Alzheimer's Disease, vascular dementia, or unspecified dementia) as the underlying cause of death or mentioned elsewhere on the death certificate. Death rates were compared using Poisson regression. Logistic regression was used to assess whether dementia was more likely to be classified as 'unspecified' type in Indigenous Australians.
The rates of death with dementia were 57% higher in Indigenous Australians, compared to non-Indigenous, relative rate (RR) 1.57, 95% confidence interval (CI) (1.48, 1.66), p < 0.0001. This excess of deaths was highest at ages below 75 (RRs > 2, test for interaction p < 0.0001), and among men (test for interaction p < 0.0001). When the underreporting of Indigenous status on the death certificate was taken into account the relative rate increased to 2.17, 95% CI (2.07, 2.29). Indigenous Australians were also more likely to have their dementia coded as 'unspecified' on their death certificate (Odds Ratio 1.92, 95% CI (1.66, 2.21), p < 0.0001), compared to the non-Indigenous group.
This epidemiological analysis based on population level mortality data demonstrates the higher dementia-related mortality rate for Indigenous Australians especially at younger ages.
痴呆症的患病率在原住民中普遍较高。
比较澳大利亚原住民和非原住民的痴呆症死亡率和编码。
使用 2006 年至 2014 年期间在澳大利亚死亡的所有年龄在 40 岁及以上人群的死因的去识别个人记录(n=1,233,084)。有 185,237 份记录的国际疾病分类,第十版,编码为痴呆症(阿尔茨海默病、血管性痴呆或未特指痴呆)作为根本死因或在死亡证明的其他地方提及。使用泊松回归比较死亡率。使用逻辑回归评估痴呆症是否更有可能在澳大利亚原住民中被归类为“未特指”类型。
与非原住民相比,澳大利亚原住民的痴呆症死亡率高出 57%,相对比率(RR)为 1.57,95%置信区间(CI)(1.48,1.66),p<0.0001。这种死亡人数的增加在 75 岁以下(RRs>2,交互检验 p<0.0001)和男性中最高(交互检验 p<0.0001)。当考虑到死亡证明中对原住民身份的漏报时,相对比率增加到 2.17,95%CI(2.07,2.29)。与非原住民相比,澳大利亚原住民的痴呆症在死亡证明上更有可能被编码为“未特指”(优势比 1.92,95%CI(1.66,2.21),p<0.0001)。
这项基于人群水平死亡率数据的流行病学分析表明,澳大利亚原住民的痴呆症相关死亡率较高,尤其是在较年轻的年龄。