Kadar N, Romero R
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.
Fertil Steril. 1988 Aug;50(2):367-70. doi: 10.1016/s0015-0282(16)60089-4.
The half-life of hCG was measured retrospectively in paired blood samples from 108 pregnancies with falling hCG levels. hCG levels fell significantly more slowly in women who had an ectopic pregnancy (41 cases) than in women who had spontaneous abortions (67 cases). When the hCG half-life was greater than or equal to 7 days, 86% of cases had ectopic pregnancies, a third of which had ruptured. By contrast, when the hCG half-life was less than 1.4 days, only 7.6% (2/26) of cases had an ectopic pregnancy (both of which were unruptured), and villi were identified in only 10% of curettage specimens from (presumed) cases of spontaneous abortion. When the half-life of hCG was between 1.4 and 6.9 days, 34% of the cases had ectopic pregnancies, 14% of which had ruptured: chorionic villi were recovered from 76% of the women who had a curettage, and failure to detect villi was more than 80% predictive of an ectopic pregnancy.
对108例人绒毛膜促性腺激素（hCG）水平下降的妊娠妇女的配对血样进行回顾性分析，以测定hCG的半衰期。与自然流产的妇女（67例）相比，异位妊娠的妇女（41例）hCG水平下降明显更慢。当hCG半衰期大于或等于7天时，86%的病例为异位妊娠，其中三分之一已破裂。相比之下，当hCG半衰期小于1.4天时，只有7.6%（2/26）的病例为异位妊娠（均未破裂），并且在（推测为）自然流产病例的刮宫标本中仅10%发现绒毛。当hCG半衰期在1.4至6.9天之间时，34%的病例为异位妊娠，其中14%已破裂：刮宫的妇女中有76%发现绒毛，未检测到绒毛对异位妊娠的预测准确率超过80%。
