Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.
J Oleo Sci. 2021 Jun 1;70(6):787-797. doi: 10.5650/jos.ess20362. Epub 2021 May 7.
1,2-Alkanediols are characteristic cosmetic ingredients because these moisturizers exhibit the antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). However, the antimicrobial behavior in mixed systems containing several active ingredients is unclear because previous reports focus on an antibacterial system containing only 1,2-alkanediol. In this study, the minimal inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were evaluated for 1,2-dodecanediol/lactic acid, 1,2-dodecanediol/myristic acid, 1,2-dodecanediol/methylparaben, and 1,2-dodecanediol/isopropyl methylphenol mixed systems to show the effect of the addition of other antimicrobial components to 1,2-dodecanediol. The antibacterial property of 1,2-dodecanediol/lactic acid mixed system was almost similar compared to 1,2-dodecanediol monomeric system. On the other hand, the antimicrobial activity of 1,2-dodecanediol against S. epidermidis was inhibited in the 1,2-dodecanediol/myristic acid mixed system. Because the selective antimicrobial activity of myristic acid against S. aureus was demonstrated in the mixed system. The present findings are useful for designing formulations of cosmetics and body cleansers containing 1,2-dodecanediol.
1,2- 烷二醇是一种有特色的化妆品成分，因为这些保湿剂对金黄色葡萄球菌（S. aureus）和表皮葡萄球菌（S. epidermidis）具有抗菌活性。然而，在含有多种活性成分的混合体系中的抗菌行为尚不清楚，因为以前的报告侧重于仅含有 1,2-烷二醇的抗菌体系。在这项研究中，评估了 1,2-十二烷二醇/乳酸、1,2-十二烷二醇/肉豆蔻酸、1,2-十二烷二醇/对羟基苯甲酸甲酯和 1,2-十二烷二醇/异丙基甲基苯酚混合体系的最小抑菌浓度（MIC）和部分抑菌浓度（FIC），以显示向 1,2-十二烷二醇中添加其他抗菌成分的效果。1,2-十二烷二醇/乳酸混合体系的抗菌性能与 1,2-十二烷二醇单体体系几乎相似。另一方面，1,2-十二烷二醇对表皮葡萄球菌的抗菌活性在 1,2-十二烷二醇/肉豆蔻酸混合体系中受到抑制。因为在混合体系中证明了肉豆蔻酸对金黄色葡萄球菌的选择性抗菌活性。本研究结果对于设计含有 1,2-十二烷二醇的化妆品和身体清洁剂配方很有用。
