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波兰重度至极重度感音神经性听力损失成人双侧人工耳蜗植入的成本-效用分析

Cost-Utility Analysis of Bilateral Cochlear Implantation in Adults With Severe to Profound Sensorineural Hearing Loss in Poland.

作者信息

Skarzynski Piotr Henryk, Ciesla Katarzyna, Lorens Artur, Wojcik Joanna, Skarzynski Henryk

机构信息

World Hearing Center, Institute of Physiology and Pathology of Hearing, Kajetany/Warsaw.

Department of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing.

出版信息

Otol Neurotol. 2021 Jun 1;42(5):706-712. doi: 10.1097/MAO.0000000000003040.

Abstract

OBJECTIVE

The aim of the study was to develop a Markov model and apply it for the evaluation of three different treatment scenarios for adult patients with severe to profound bilateral sensorineural hearing loss.

STUDY DESIGN

Prospective Observational Study.

SETTINGS

Hospital.

PATIENTS

A clinical group of 22 adult patients (59.1% men, 40.9% women) aged from 59.13 ± 8.9 years were included in the study. The study comprised two arms: patients in group 1 received the second cochlear implant one to three months after the first implant; while patients in group 2 got the second cochlear implant approximately one year after the first implant.

MAIN OUTCOME MEASURES

All participants were first asked to complete an AQoL-8D questionnaire. For the cost-effectiveness analyses, a Markov model analyzed as microsimulation was developed to compare the different treatment options.

RESULTS

The analyses show that bilateral cochlear implantation strategies are cost-effective compared to the 'no treatment' alternative when having a 10-year model time horizon. When all three model scenarios are compared, the bilateral simultaneous cochlear implantation strategy (Scenario 3) compared to the 'no treatment' option is even more cost-effective than the Scenarios 1 and 2, compared with the 'no treatment' alternative.

CONCLUSIONS

The model results summarize that bilateral (sequential and simultaneous) cochlear implantation that are represented in the model scenarios, are cost-effective strategies for Polish adult patients with bilateral severe to profound sensorineural hearing loss.

摘要

目的

本研究旨在建立一个马尔可夫模型,并将其应用于评估成年重度至极重度双侧感音神经性听力损失患者的三种不同治疗方案。

研究设计

前瞻性观察性研究。

研究地点

医院。

患者

本研究纳入了22名成年患者的临床组(男性占59.1%,女性占40.9%),年龄为59.13±8.9岁。该研究包括两个组:第1组患者在首次植入人工耳蜗后1至3个月接受第二次植入;而第2组患者在首次植入人工耳蜗后约一年接受第二次植入。

主要观察指标

所有参与者首先被要求完成一份AQoL - 8D问卷。为了进行成本效益分析,开发了一个作为微观模拟分析的马尔可夫模型,以比较不同的治疗方案。

结果

分析表明,在10年的模型时间范围内,与“不治疗”方案相比,双侧人工耳蜗植入策略具有成本效益。当比较所有三种模型方案时,与“不治疗”方案相比,双侧同时人工耳蜗植入策略(方案3)比方案1和方案2更具成本效益。

结论

模型结果总结表明,模型方案中所代表的双侧(序贯和同时)人工耳蜗植入是波兰成年双侧重度至极重度感音神经性听力损失患者的成本效益策略。

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