Rocamonde Brenda, Herranz-Pérez Vicente, Garcia-Verdugo Jose Manuel, Huillard Emmanuelle
INSERM, CNRS, APHP, Institut du Cerveau - Paris Brain Institute (ICM), Sorbonne Université, Paris, France.
Laboratory of Comparative Neurobiology, CIBERNED, Institute Cavanilles, University of Valencia, Valencia, Spain.
Front Neurosci. 2021 Apr 22;15:668243. doi: 10.3389/fnins.2021.668243. eCollection 2021.
Ependymal cells are radial glia-derived multiciliated cells lining the lateral ventricles of the brain and spinal cord. Correct development and coordinated cilia beating is essential for proper cerebrospinal fluid (CSF) flow and neurogenesis modulation. Dysfunctions of ependymal cells were associated with transcription factor deregulation. Here we provide evidence that the transcriptional regulator ID4 is involved in ependymal cell development and maturation. We observed that -deficient mice display altered ventricular cell cytoarchitecture, decreased ependymal cell number and enlarged ventricles. In addition, absence of ID4 during embryonic development resulted in decreased ependymal cell number and delayed maturation. Our findings open the way for a potential role of ID4 in ependymal cell development and motor cilia function.
室管膜细胞是源自放射状胶质细胞的多纤毛细胞，排列在脑和脊髓的侧脑室。正确的发育和协调的纤毛摆动对于脑脊液（CSF）的正常流动和神经发生调节至关重要。室管膜细胞功能障碍与转录因子失调有关。在这里，我们提供证据表明转录调节因子ID4参与室管膜细胞的发育和成熟。我们观察到，ID4缺陷小鼠的脑室细胞细胞结构发生改变，室管膜细胞数量减少，脑室扩大。此外，胚胎发育期间ID4的缺失导致室管膜细胞数量减少和成熟延迟。我们的研究结果为ID4在室管膜细胞发育和运动纤毛功能中的潜在作用开辟了道路。
