Deng Shiyu, Gan Lin, Liu Chang, Xu Tongtong, Zhou Shiyi, Guo Yiyan, Zhang Zhijun, Yang Guo-Yuan, Tian Hengli, Tang Yaohui
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Aging Dis. 2023 Apr 1;14(2):468-483. doi: 10.14336/AD.2022.0826-1.
Ependymal cells are indispensable components of the central nervous system (CNS). They originate from neuroepithelial cells of the neural plate and show heterogeneity, with at least three types that are localized in different locations of the CNS. As glial cells in the CNS, accumulating evidence demonstrates that ependymal cells play key roles in mammalian CNS development and normal physiological processes by controlling the production and flow of cerebrospinal fluid (CSF), brain metabolism, and waste clearance. Ependymal cells have been attached to great importance by neuroscientists because of their potential to participate in CNS disease progression. Recent studies have demonstrated that ependymal cells participate in the development and progression of various neurological diseases, such as spinal cord injury and hydrocephalus, raising the possibility that they may serve as a potential therapeutic target for the disease. This review focuses on the function of ependymal cells in the developmental CNS as well as in the CNS after injury and discusses the underlying mechanisms of controlling the functions of ependymal cells.
室管膜细胞是中枢神经系统（CNS）不可或缺的组成部分。它们起源于神经板的神经上皮细胞，具有异质性，至少有三种类型，分布于中枢神经系统的不同位置。作为中枢神经系统中的神经胶质细胞，越来越多的证据表明，室管膜细胞通过控制脑脊液（CSF）的产生和流动、脑代谢及废物清除，在哺乳动物中枢神经系统发育和正常生理过程中发挥关键作用。由于室管膜细胞具有参与中枢神经系统疾病进展的潜力，神经科学家对其高度重视。最近的研究表明，室管膜细胞参与各种神经系统疾病的发生和发展，如脊髓损伤和脑积水，这增加了它们可能成为该疾病潜在治疗靶点的可能性。本文综述了室管膜细胞在发育中的中枢神经系统以及损伤后中枢神经系统中的功能，并探讨了控制室管膜细胞功能的潜在机制。
