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衰老对人类补充乳果糖的混合固液餐胃肠道转运的影响。

Effect of ageing on the gastro-intestinal transit of a lactulose-supplemented mixed solid-liquid meal in humans.

作者信息

Wegener M, Börsch G, Schaffstein J, Lüth I, Rickels R, Ricken D

机构信息

Medizinische Klinik, Ruhr-Universität Bochum, BRD.

出版信息

Digestion. 1988;39(1):40-6. doi: 10.1159/000199606.

DOI:10.1159/000199606
PMID:3396772
Abstract

Gastro-intestinal transit of a mixed solid-liquid meal containing wheat bread, scrambled eggs, coffee labelled with 99mTc, orange juice with lactulose and indigocarmine was evaluated in 21 young control (mean age 33.5 years) and 25 elderly subjects (mean age 81.7 years) without gastrointestinal complaints or severe medical illness. The rate of gastric emptying was determined by an anterior gamma camera technique, mouth-to-caecum transit by the hydrogen breath test and whole-gut transit by the first stool passage of indigocarmine. Gastric emptying was significantly prolonged in older subjects: t1/2 = 136 +/- (SEM) 13 versus 81 +/- 4 min; p less than 0.001. Concerning mouth-to-caecum or whole-gut transit time, significant differences between the two study groups were not detected.

摘要

在21名无胃肠道不适或严重疾病的年轻对照者(平均年龄33.5岁)和25名老年受试者(平均年龄81.7岁)中,评估了含有小麦面包、炒鸡蛋、标记有99mTc的咖啡、含乳果糖和靛胭脂的橙汁的混合固液餐的胃肠道转运情况。通过前位γ相机技术测定胃排空率,通过氢呼气试验测定口至盲肠转运时间,通过靛胭脂首次随粪便排出测定全肠道转运时间。老年受试者的胃排空明显延长:t1/2 = 136±(标准误)13分钟,而年轻对照者为81±4分钟;p<0.001。关于口至盲肠或全肠道转运时间,未检测到两个研究组之间存在显著差异。

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