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地理纬度仍是某些肌炎自身抗体流行的重要因素:系统评价。

Geographical Latitude Remains as an Important Factor for the Prevalence of Some Myositis Autoantibodies: A Systematic Review.

机构信息

Centro Universitario de Ciencias de la Salud, Doctorado en Ciencias Biomédicas, Universidad de Guadalajara, Guadalajara, Mexico.

Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Reumatología y del Sistema Músculo-Esquelético (IIRSME), Universidad de Guadalajara, Guadalajara, Mexico.

出版信息

Front Immunol. 2021 Apr 22;12:672008. doi: 10.3389/fimmu.2021.672008. eCollection 2021.

Abstract

The idiopathic inflammatory myopathies (IIM) are characterized by muscular weakness, cutaneous manifestations, muscle damage revealed by increase of muscular enzymes, muscle biopsy, electromyography and changes on magnetic resonance imaging. However, the hallmark of these IIM, is the development of myositis specific antibodies (MSA) or myositis associated antibodies (MAA). The theories about their presence in the serum of IIM is not known. Some studies have suggested that some of these MSA, such as anti-Mi-2 increases according to the intensity of UV radiation. There is scarce information about the environmental factors that might contribute in order to be considered as triggering factors as UV radiation might be. In this review, we analyzed the reported prevalence of MSAs and MAAs regarding to their geographical location and the possible relation with UV radiation. We collected the prevalence data of fifteen MSA and thirteen MAA from 22 countries around the world and we were able to observe a difference in prevalence between countries and continents. We found differences in anti-PL7, anti-Ro52, anti-La and anti-Ku prevalence according to UV radiation level. Otherwise, we observed that anti-Mi-2 prevalence increases near to the Equator meanwhile anti-MJ/NXP2 and anti-ARS prevalence had an opposite behavior increasing their prevalence in the geographical locations farther to the Equator. Our results highlighted the importance to include the UV radiation and other environmental factors in IIM studies, in order to clarify its association with MSA and MAA prevalence as well as its possible role in the immunopathogenesis of these diseases.

摘要

特发性炎性肌病(IIM)的特征是肌肉无力、皮肤表现、肌肉酶升高提示肌肉损伤、肌肉活检、肌电图和磁共振成像改变。然而,这些 IIM 的标志是肌炎特异性抗体(MSA)或肌炎相关抗体(MAA)的出现。这些 MSA 在 IIM 血清中的存在的理论尚不清楚。一些研究表明,某些 MSA,如抗 Mi-2,会根据紫外线辐射的强度增加。关于可能作为触发因素的环境因素的信息很少,因为紫外线辐射可能就是其中之一。在这篇综述中,我们分析了报告的 MSA 和 MAA 的流行率,以及它们与地理位置的关系和可能与紫外线辐射的关系。我们收集了来自世界各地 22 个国家的 15 种 MSA 和 13 种 MAA 的流行率数据,我们能够观察到国家和大洲之间的流行率差异。我们发现抗 PL7、抗 Ro52、抗 La 和抗 Ku 的流行率根据紫外线辐射水平而有所不同。另一方面,我们观察到抗 Mi-2 的流行率在接近赤道的地方增加,而抗 MJ/NXP2 和抗 ARS 的流行率则相反,在远离赤道的地方增加。我们的结果强调了在 IIM 研究中纳入紫外线辐射和其他环境因素的重要性,以阐明其与 MSA 和 MAA 流行率的关系及其在这些疾病免疫发病机制中的可能作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecbf/8100663/706653b57af5/fimmu-12-672008-g001.jpg

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