Aschenbrenner Andrew J, Baksh R Asaad, Benejam Bessy, Beresford-Webb Jessica A, Coppus Antonia, Fortea Juan, Handen Benjamin L, Hartley Sigan, Head Elizabeth, Jaeger Judith, Levin Johannes, Loosli Sandra V, Rebillat Anne-Sophie, Sacco Silvia, Schmitt Frederick A, Thurlow Kate E, Zaman Shahid, Hassenstab Jason, Strydom Andre
Washington University in St. Louis, Department of Neurology St. Louis Missouri USA.
Institute of Psychiatry, Psychology, and Neuroscience Department of Forensic and Neurodevelopmental Sciences King's College London London UK.
Alzheimers Dement (Amst). 2021 May 2;13(1):e12184. doi: 10.1002/dad2.12184. eCollection 2021.
Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting pre-dementia stages.
We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. We then conducted additional analyses to provide support for the utility of the composites. The composites were presented to an expert panel to determine the most optimal cognitive battery based on predetermined criteria.
There were common cognitive domains across site composites, which were sensitive to early decline. The final composite consisted of memory, language/executive functioning, selective attention, orientation, and praxis tests.
We have identified a composite that is sensitive to early decline and thus may have utility as an outcome measure in trials to prevent or delay symptoms of AD in DS.
唐氏综合征（DS）是早发性阿尔茨海默病（AD）的一种基因变异型，针对痴呆前期阶段的预防试验缺乏合适的结局指标。
我们使用了国际上几项纵向衰老研究中收集的认知测试数据，这些数据来自312名无痴呆的DS参与者，以确定对随时间变化敏感的综合指标。然后我们进行了额外的分析，以支持这些综合指标的实用性。将这些综合指标提交给一个专家小组，根据预定标准确定最优化的认知测试组合。
各研究点的综合指标中有共同的认知领域，这些领域对早期衰退敏感。最终的综合指标包括记忆、语言/执行功能、选择性注意、定向和实践测试。
我们已经确定了一个对早期衰退敏感的综合指标，因此它可能作为一种结局指标用于预防或延缓DS中AD症状的试验。
