Fleming Walsh Sharon, Balster Courtney, Chandler Aaron, Brown Jennifer, Boehler Mark, O'Rear Stephen
Physical Therapy, University of Findlay, Findlay, OH, USA.
Physiother Theory Pract. 2022 May;38(5):629-636. doi: 10.1080/09593985.2020.1780655. Epub 2020 Jun 17.
The purpose of this study was to determine the long-term effects of LSVT BIG® on the function of individuals with Parkinson's Disease (PD).
Eighteen participants gave informed consent, and met the inclusion criteria. Time since diagnosis of PD ranged from .5 to 16 years (mean 4.5 years), time since discharge from 3-23 months (mean 6.5 months). Hoehn and Yahr scores were from 2 to 4. Subjects were posttested by blinded evaluators on the same 8 measures used at evaluation and discharge, the 6 Minute Walk (6WMT), Timed Up and Go (TUG), TUG-manual, TUG-cognitive, 10 Meter Walk(10MWT), 30 Second Sit to Stand (30 CST), Berg Balance Scale (BBS), and the Functional Gait Assessment (FGA). Test means were compared from evaluation to discharge, discharge to posttesting, and evaluation to posttest using repeated measures ANOVA with a Tukey correction, value < .05.
The time between discharge and posttesting was not a confounding variable. Significant improvement in all measures were displayed from evaluation to discharge. No significant change was found from discharge to posttesting except for 6MWT. Significant improvements were noted when comparing initial evaluation to posttesting: TUG = .001; TUG-manual = .003; TUG-cognitive = .001; 10MWT < .001; BBS < .001; and FGA < .001.
Subjects were able to maintain significant gains noted at discharge from the program in measures of functional mobility and balance. The exception was endurance, as assessed by the 6MWT and the 30 CST. This suggests that the LSVT BIG® protocol has the potential for long term improvement in functional mobility in individuals with PD.
本研究旨在确定大剂量语音治疗（LSVT BIG®）对帕金森病（PD）患者功能的长期影响。
18名参与者签署了知情同意书，并符合纳入标准。帕金森病诊断后的时间范围为0.5至16年（平均4.5年），出院后的时间范围为3至23个月（平均6.5个月）。Hoehn和Yahr评分在2至4之间。受试者由盲法评估者使用评估和出院时相同的8项指标进行后测，包括6分钟步行试验（6WMT）、定时起立行走试验（TUG）、手动定时起立行走试验（TUG-手动）、认知定时起立行走试验（TUG-认知）、10米步行试验（10MWT）、30秒坐立试验（30 CST）、伯格平衡量表（BBS）和功能性步态评估（FGA）。使用重复测量方差分析和Tukey校正比较评估、出院和后测的测试均值，P值<0.05。
出院和后测之间的时间不是一个混杂变量。从评估到出院，所有指标均有显著改善。除6MWT外，出院到后测未发现显著变化。将初始评估与后测进行比较时，发现有显著改善：TUG，P = 0.001；TUG-手动，P = 0.003；TUG-认知，P = 0.001；10MWT，P < 0.001；BBS，P < 0.001；FGA，P < 0.001。
受试者能够在功能移动性和平衡测量方面维持在项目出院时所取得的显著进展。耐力是个例外，通过6MWT和30 CST评估。这表明LSVT BIG®方案有可能长期改善帕金森病患者的功能移动性。
