Cloning and expression of human nebulin cDNAs and assignment of the gene to chromosome 2q31-q32.
作者信息
Zeviani M, Darras B T, Rizzuto R, Salviati G, Betto R, Bonilla E, Miranda A F, Du J, Samitt C, Dickson G
机构信息
H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Disorders, Columbia University, New York, New York 10032.
出版信息
Genomics. 1988 Apr;2(3):249-56. doi: 10.1016/0888-7543(88)90009-2.
We have isolated two nonoverlapping cDNAs encoding human nebulin, a muscle-specific protein. Northern hybridization analysis shows that nebulin is encoded by a huge message at least 25 kb in length. By hybridizing two nonoverlapping cDNAs to DNA isolated from rodent X human cell hybrids, we assign this presumably single-copy gene to human chromosome 2; sublocalization studies indicate that the nebulin gene is on the long arm of the chromosome, in the region 2q31-q32.
Zotero 插件