环境中非产抗真菌素 viridin 的微生物将 antifungal viridin 生物转化为植物毒素 viridiol。

Bioconversion of antifungal viridin to phytotoxin viridiol by environmental non-viridin producing microorganisms.

机构信息

Laboratoire Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle, CNRS; CP54, 57 Rue Cuvier, 75005 Paris, France; Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université Félix Houphouët Boigny d'Abidjan (UFHB), 22 BP 582 Abidjan 22, Cote d'Ivoire.

Laboratoire Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle, CNRS; CP54, 57 Rue Cuvier, 75005 Paris, France.

出版信息

Bioorg Chem. 2021 Jul;112:104959. doi: 10.1016/j.bioorg.2021.104959. Epub 2021 May 1.

DOI:10.1016/j.bioorg.2021.104959

PMID:33971564

Abstract

Biotransformation of viridin, an antifungal produced by biocontrol agent, with non-viridin producing microorganisms is studied. The results show that some environmental non-targeted microorganisms are able to reduce it in the known phytotoxin viridiol, and its 3-epimer. Consequently, this reduction, which happens in some cases by detoxification mechanism, could be disastrous for the plant in a biocontrol of plant disease. However, a process fermentation/biotransformation could be an efficient approach for the preparation of this phytotoxin.

摘要

生物防治剂产生的抗真菌物质 viridin 的生物转化研究，与非 viridin 产生微生物一起研究。结果表明，一些环境非靶标微生物能够将其还原为已知植物毒素 viridiol 和其 3-差向异构体。因此，这种还原反应（在某些情况下是通过解毒机制发生的）可能对植物病害的生物防治中的植物造成灾难性影响。然而，发酵/生物转化过程可能是制备这种植物毒素的有效方法。