iBET - Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal; LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, FCT NOVA, Universidade NOVA de Lisboa, Caparica, Portugal.
Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Sci Total Environ. 2021 Sep 10;786:147477. doi: 10.1016/j.scitotenv.2021.147477. Epub 2021 Apr 30.
The occurrence of six anticancer drugs was evaluated in wastewater effluents. Several grab samples from wastewater effluent were collected throughout a year. Capecitabine, cyclophosphamide and ifosfamide were detected at concentrations ranging from 8 to 46 ng·L. Capecitabine was detected in all the sampling events whereas cyclophosphamide and ifosfamide were detected less frequently. Additionally, the suitability of using pharmaceutical-polar organic chemical integrative samplers (POCIS) to monitor the target drugs in wastewater effluents was assessed. Capecitabine, ifosfamide and cyclophosphamide were detected with POCIS and showed a linear uptake over 15 days. The sampling rates, determined in situ, were used to estimate time-weighted average concentrations. A good correlation was found between the concentration of capecitabine detected with POCIS deployed during five days (32 ± 1 ng·L) and the average concentrations obtained in grab samples. The use of passive samplers has advantages over grab samples: easier analysis, less time and costs associated with the analytical method. Passive samplers also provide a time-weighted information about the concentration of pollutants in the aquatic environment. However, information may be lost when the concentration of the target compounds in wastewater effluents is low and the passive samplers are deployed for a short time.
评估了废水中六种抗癌药物的出现情况。在一年中，从废水中采集了多个随机样本。卡培他滨、环磷酰胺和异环磷酰胺的浓度范围为 8 至 46 ng·L。卡培他滨在所有采样事件中均有检出，而环磷酰胺和异环磷酰胺的检出频率较低。此外，还评估了使用药物-极性有机化学综合采样器（POCIS）监测废水中目标药物的适用性。卡培他滨、异环磷酰胺和环磷酰胺可以用 POCIS 检测到，并在 15 天内呈现线性吸收。在现场测定的采样速率用于估计时间加权平均浓度。在五天内（32 ± 1 ng·L）部署的 POCIS 检测到的卡培他滨浓度与随机样本获得的平均浓度之间存在良好的相关性。与随机采样相比，使用被动采样器具有以下优势：分析更简单，与分析方法相关的时间和成本更少。被动采样器还提供了关于水环境污染中污染物浓度的时间加权信息。然而，当废水中目标化合物的浓度较低且被动采样器的部署时间较短时，可能会丢失信息。
