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[Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia].[静脉血栓栓塞症和高同型半胱氨酸血症作为恶性贫血的首发表现]
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Hyperhomocysteinemia-associated Thrombosis in Patients With Pernicious Anemia.恶性贫血患者高同型半胱氨酸血症相关性血栓形成
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Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review.与自身免疫性胃炎相关的高同型半胱氨酸血症和缺铁性贫血引起的脑静脉血栓形成：病例报告及文献复习。
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本文引用的文献

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Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia: a case series.静脉血栓栓塞症和高同型半胱氨酸血症作为恶性贫血的首发表现：病例系列
J Med Case Rep. 2017 Sep 2;11(1):250. doi: 10.1186/s13256-017-1415-z.
2
Study on relationships among deep vein thrombosis, homocysteine & related B group vitamins.深静脉血栓形成、同型半胱氨酸及相关B族维生素之间的关系研究
Pak J Med Sci. 2015 Mar-Apr;31(2):398-402. doi: 10.12669/pjms.312.6049.
3
Portal, superior mesenteric and splenic vein thrombosis secondary to hyperhomocysteinemia with pernicious anemia: a case report.伴有恶性贫血的高同型半胱氨酸血症继发门静脉、肠系膜上静脉和脾静脉血栓形成：一例报告
J Med Case Rep. 2014 Aug 25;8:286. doi: 10.1186/1752-1947-8-286.
4
Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center.三级医疗中心脑静脉窦血栓形成的临床特征与转归
J Neurosci Rural Pract. 2014 Jul;5(3):218-24. doi: 10.4103/0976-3147.133559.
5
Recurrent unprovoked venous thromboembolism in a young female patient with high levels of homocysteine.一名高同型半胱氨酸水平的年轻女性患者反复出现不明原因的静脉血栓栓塞。
Int J Angiol. 2012 Jun;21(2):95-8. doi: 10.1055/s-0032-1315626.
6
Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis.脑静脉血栓形成患者的危险因素和复发性血栓事件。
Blood Transfus. 2014 Jan;12 Suppl 1(Suppl 1):s337-42. doi: 10.2450/2013.0196-12. Epub 2013 Feb 6.
7
Guidelines on the investigation and management of venous thrombosis at unusual sites.特殊部位静脉血栓形成的调查与处理指南
Br J Haematol. 2012 Oct;159(1):28-38. doi: 10.1111/j.1365-2141.2012.09249.x. Epub 2012 Aug 9.
8
Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association.脑静脉血栓形成的诊断和治疗：美国心脏协会/美国中风协会向医疗保健专业人员的声明。
Stroke. 2011 Apr;42(4):1158-92. doi: 10.1161/STR.0b013e31820a8364. Epub 2011 Feb 3.
9
Homocysteine and peripheral arterial disease: systematic review and meta-analysis.同型半胱氨酸与外周动脉疾病：系统评价与荟萃分析
Eur J Vasc Endovasc Surg. 2009 Sep;38(3):316-22. doi: 10.1016/j.ejvs.2009.05.007. Epub 2009 Jun 27.
10
Acute myocardial infarction and pulmonary embolism in a young man with pernicious anemia-induced severe hyperhomocysteinemia.年轻男性因恶性贫血导致严重高同型半胱氨酸血症而发生急性心肌梗死和肺栓塞。
Thromb J. 2009 May 13;7:5. doi: 10.1186/1477-9560-7-5.

恶性贫血：复发性脑静脉血栓形成的病因。

Pernicious anaemia: cause of recurrent cerebral venous thrombosis.

机构信息

Department of Medicine, Baroda Medical College, Vadodara, Gujarat, India

Baroda Medical College, Vadodara, Gujarat, India.

出版信息

BMJ Case Rep. 2021 May 10;14(5):e239833. doi: 10.1136/bcr-2020-239833.

DOI:10.1136/bcr-2020-239833
PMID:33972295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8112394/
Abstract

This case of recurrent cerebral venous thrombosis (CVT) highlights hyperhomocysteinemia in pernicious anemia due to vitamin B deficiency. No other risk factors such as trauma, infections, coagulation disorders or autoimmune diseases were present. The patient was cured with vitamin B and anticoagulation therapy. So, it is worthwhile and important to investigate levels of vitamin B and homocysteine in CVT.

摘要

本病例为复发性脑静脉血栓形成（CVT），提示因维生素 B12 缺乏导致的恶性贫血伴高同型半胱氨酸血症。无创伤、感染、凝血障碍或自身免疫性疾病等其他危险因素。患者经维生素 B12 和抗凝治疗后痊愈。因此，对 CVT 患者进行维生素 B12 和同型半胱氨酸水平的检测是值得且重要的。