Binghamton Biofilm Research Center, Department of Biology, Binghamton University, Binghamton, New York, USA.
Infect Immun. 2021 Jul 15;89(8):e0018521. doi: 10.1128/IAI.00185-21.
M-type 28 (M28) Streptococcus pyogenes (group A Streptococcus [GAS]) strains are highly associated with life-threatening puerperal infections. Genome sequencing has revealed a large mobile genetic element, RD2, present in most M28 GAS isolates but not found widely in other serotypes. Previous studies have linked RD2 to the ability of M28 GAS to colonize the vaginal tract. A new study by Roshika and colleagues (R. Roshika, I. Jain, J. Medicielo, J. Wächter, J. L. Danger, P. Sumby, Infect Immun 89:e00722-20, 2021, https://doi.org/10.1128/IAI.00722-20) used gain-of-function mutants in three different GAS serotypes to help determine why RD2 appears to have a serotype preference and what that could mean for GAS mucosal colonization and pathogenesis.
M 型 28（M28）化脓性链球菌（A 组链球菌[GAS]）菌株与危及生命的产褥期感染高度相关。基因组测序揭示了一种存在于大多数 M28 GAS 分离株中的大型移动遗传元件 RD2，但在其他血清型中并不广泛发现。先前的研究将 RD2 与 M28 GAS 定植阴道的能力联系起来。Roshika 及其同事（R. Roshika、I. Jain、J. Medicielo、J. Wächter、J. L. Danger、P. Sumby，Infect Immun 89:e00722-20，2021，https://doi.org/10.1128/IAI.00722-20）使用三种不同 GAS 血清型的功能获得性突变体来帮助确定为什么 RD2 似乎具有血清型偏好，以及这对 GAS 黏膜定植和发病机制意味着什么。
