Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Department of Pathology Anatomy, Faculty of Medicine, Padjadjaran University - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Am J Case Rep. 2021 May 11;22:e930789. doi: 10.12659/AJCR.930789.
BACKGROUND Gestational trophoblastic disease (GTD) encompasses a group of disorders that arise from abnormal growth of trophoblastic tissue. The spectrum of GTD includes 2 major groups: benign and malignant. The benign form is a hydatidiform mole, either complete or partial; the malignant forms, referred to as gestational trophoblastic neoplasia (GTN), consist of invasive moles, choriocarcinomas, placental site trophoblastic tumors, and epithelioid trophoblastic tumors. Most patients who undergo evacuation of a hydatidiform mole by curettage have a disease-free period before a new tumor develops that can be considered malignant. In rare cases, metastasis occurs rapidly and manifests coincidentally before the hydatidiform mole can be evacuated. CASE REPORT A 19-year-old woman in Bandung City, West Java, Indonesia, was diagnosed with a molar pregnancy with early evidence of a mass in her vagina that was suspicious for stage II GTN. The early emergence of a vaginal mass was a rare case of early transformation of a molar pregnancy into GTN. CONCLUSIONS Careful evaluation is warranted of patients with characteristics typical of an intrauterine molar pregnancy who have an early presentation of a vaginal mass because of the possibility that the diagnosis could be GTN.
妊娠滋养细胞疾病（GTD）包括一组源于滋养细胞异常生长的疾病。GTD 的范围包括 2 个主要类别：良性和恶性。良性形式为葡萄胎，完全或部分性；恶性形式为妊娠滋养细胞肿瘤（GTN），包括侵袭性葡萄胎、绒毛膜癌、胎盘部位滋养细胞肿瘤和上皮样滋养细胞肿瘤。大多数接受刮宫术清除葡萄胎的患者在新肿瘤发展之前有一段无病期，可被认为是恶性的。在极少数情况下，转移迅速发生，并在可以清除葡萄胎之前同时出现。病例报告：印度尼西亚西爪哇省万隆市一名 19 岁女性被诊断为葡萄胎妊娠，阴道内有肿块的早期迹象，疑似 II 期 GTN。阴道肿块的早期出现是葡萄胎妊娠早期转化为 GTN 的罕见病例。结论：对于具有典型宫内葡萄胎特征且阴道肿块早期出现的患者，应进行仔细评估，因为可能诊断为 GTN。
