Gómez Alonso A, Cuadrado Idoyaga F, Villar Galan J L, Pérez Garcia A, Rodriguez Morán M, Milicua M, Cabezas J A, Pérez Gonzalez M N
Departamento de Cirugía, Facultad de Medicina, Universidad de Salamanca, Spain.
Int Surg. 1988 Apr-Jun;73(2):91-3.
The infective factor seems to be very important in the physiopathology of intestinal ischaemia syndrome, as we suggested in previous research works, and is probably responsible for the disturbances observed in pulmonary surfactant. In the present research project, 48 mongrel dogs were studied under different situations of experimental intestinal ischaemia (arterial, venous and revascularization) after laparotomy and the pulmonary surfactant was determined in all cases. We conclude that the observed changes in phospholipids (phosphatidylglycerol and phosphatidylinositol particularly) can be directly related to the infective factor and important enough to induce physicochemical alterations of the surfactant and subsequently pulmonary function.
正如我们在先前的研究中所指出的，感染因素在肠缺血综合征的病理生理过程中似乎非常重要，并且可能是导致肺表面活性物质出现紊乱的原因。在本研究项目中，对48只杂种犬在剖腹术后处于不同实验性肠缺血情况（动脉性、静脉性和再灌注）下进行了研究，并测定了所有病例的肺表面活性物质。我们得出结论，观察到的磷脂（尤其是磷脂酰甘油和磷脂酰肌醇）变化可能与感染因素直接相关，并且其重要性足以引起表面活性物质的物理化学改变，进而导致肺功能变化。
