• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

吡喃葡萄糖基共轭苄基衍生物作为新型结肠癌选择性细胞毒剂的合成及药理学特性研究

Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer.

作者信息

Fu Boqiao, Li Yingjie, Peng Shaoyong, Wang Xiaolin, Hu Jingying, Lv Long, Xia Caifen, Lu Dai, Qin Caiqin

机构信息

Hubei Provincial Collaborative Innovation Center of Biomass Resources Transformation and Utilization, College of Chemistry and Materials Science, Hubei Engineering University, Hubei 432000, People's Republic of China.

Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, People's Republic of China.

出版信息

R Soc Open Sci. 2021 Feb 24;8(2):201642. doi: 10.1098/rsos.201642.

DOI:10.1098/rsos.201642
PMID:33972860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8074679/
Abstract

Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of is achieved through triggering apoptotic cell death.

摘要

合成了含有[1,2,3]-三唑连接基的吡喃葡萄糖基共轭苄基衍生物。苄基是抗癌化合物中的重要药效基团。该化合物抑制结肠癌细胞的增殖，其效力与5-氟尿嘧啶（5-FU）相当，且对癌细胞的选择性有所提高。该化合物的抗增殖活性是通过引发凋亡性细胞死亡来实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/7b8a37383492/rsos201642f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/bdbe9d1dcc9b/rsos201642f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/f88c9eca9b09/rsos201642f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/26604f8cf3c2/rsos201642f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/7b8a37383492/rsos201642f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/bdbe9d1dcc9b/rsos201642f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/f88c9eca9b09/rsos201642f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/26604f8cf3c2/rsos201642f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b313/8074679/7b8a37383492/rsos201642f02.jpg

相似文献

1
Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer.吡喃葡萄糖基共轭苄基衍生物作为新型结肠癌选择性细胞毒剂的合成及药理学特性研究
R Soc Open Sci. 2021 Feb 24;8(2):201642. doi: 10.1098/rsos.201642.
2
Synthesis and antiproliferative evaluation of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold.含苯并异硒唑酮骨架的新型1,2,4-三唑衍生物的合成与抗增殖活性评价
Bioorg Med Chem Lett. 2016 Feb 15;26(4):1279-81. doi: 10.1016/j.bmcl.2016.01.017. Epub 2016 Jan 8.
3
Novel -amide-based bis-thiazoles as Anti-colorectal Cancer Agents Through Bcl-2 Inhibition: Synthesis, , and studies.新型酰胺基双噻唑类 Bcl-2 抑制剂的合成、 及 研究及其作为抗结直肠癌药物的应用。
Anticancer Agents Med Chem. 2023;23(3):328-345. doi: 10.2174/1871520622666220615140239.
4
Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents.作为抗增殖剂的戈尼辛和荜茇亭的 4-羟基衍生物的杂种，带有二酯或 1,2,3-三唑连接体。
Bioorg Chem. 2021 Nov;116:105292. doi: 10.1016/j.bioorg.2021.105292. Epub 2021 Aug 25.
5
Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells.三七增强5-氟尿嘧啶对人结肠癌细胞的抗癌作用。
Cancer Chemother Pharmacol. 2007 Jun;60(1):69-79. doi: 10.1007/s00280-006-0350-2. Epub 2006 Sep 29.
6
Design and synthesis of novel phenylaminopyrimidines with antiproliferative activity against colorectal cancer.具有抗结直肠癌增殖活性的新型苯氨基嘧啶的设计与合成
RSC Adv. 2019 Jul 11;9(37):21578-21586. doi: 10.1039/c9ra03359a. eCollection 2019 Jul 5.
7
New Schiff bases derived from dimethylpyridine-1,2,4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological evaluation and molecular docking studies.新型希夫碱类化合物的设计、合成、生物评价及分子对接研究，这些化合物以二甲基吡啶-1,2,4-三唑杂合为基础，作为针对胃肠道癌症的细胞毒剂。
Bioorg Chem. 2023 Oct;139:106758. doi: 10.1016/j.bioorg.2023.106758. Epub 2023 Jul 31.
8
Synthesis and anticancer activity of dimeric podophyllotoxin derivatives.二聚体鬼臼毒素衍生物的合成及其抗癌活性
Drug Des Devel Ther. 2018 Oct 9;12:3393-3406. doi: 10.2147/DDDT.S167382. eCollection 2018.
9
New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.新型 1,2,4-三唑/吡唑杂合体与肟部分相连作为一氧化氮供体塞来昔布类似物：合成、环氧化酶抑制抗炎、致溃疡、抗增殖活性、细胞凋亡、分子模拟和一氧化氮释放研究。
Bioorg Chem. 2020 May;98:103752. doi: 10.1016/j.bioorg.2020.103752. Epub 2020 Mar 12.
10
Design, Synthesis and Biological Activity Evaluation of S-Substituted 1-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer.S-取代的1-（5-巯基-1,2,4-三唑）衍生物作为结直肠癌抗增殖剂的设计、合成及生物活性评价
Front Chem. 2018 Aug 23;6:373. doi: 10.3389/fchem.2018.00373. eCollection 2018.

引用本文的文献

1
Design and Synthesis of Thiourea-Conjugating Organic Arsenic D-Glucose with Anticancer Activities.设计与合成具有抗癌活性的硫脲连接的有机砷-D-葡萄糖。
Molecules. 2024 Jun 14;29(12):2850. doi: 10.3390/molecules29122850.
2
Asymmetric α-benzylation of cyclic ketones enabled by concurrent chemical aldol condensation and biocatalytic reduction.通过同时进行的化学羟醛缩合和生物催化还原实现环状酮的不对称 α-苄基化。
Nat Commun. 2024 Jan 2;15(1):71. doi: 10.1038/s41467-023-44452-z.
3
Value of MSCT plus MRI in the Detection of Colon Cancer.多层螺旋CT（MSCT）联合磁共振成像（MRI）在结肠癌检测中的价值

本文引用的文献

1
Carbohydrate-conjugated 4-(1,3,2-dithiarsolan-2-yl)aniline as a cytotoxic agent against colorectal cancer.碳水化合物共轭的4-(1,3,2-二硫砷杂环戊烷-2-基)苯胺作为一种抗结直肠癌的细胞毒性剂。
RSC Adv. 2018 Dec 5;8(71):40760-40764. doi: 10.1039/c8ra07860b. eCollection 2018 Dec 4.
2
Modular click chemistry libraries for functional screens using a diazotizing reagent.使用重氮化试剂的用于功能筛选的模块化点击化学文库。
Nature. 2019 Oct;574(7776):86-89. doi: 10.1038/s41586-019-1589-1. Epub 2019 Oct 2.
3
1-1,2,3-Triazole Tethered Nitroimidazole-Isatin Conjugates: Synthesis, Docking, and Anti-Proliferative Evaluation against Breast Cancer.
Evid Based Complement Alternat Med. 2022 May 31;2022:6507865. doi: 10.1155/2022/6507865. eCollection 2022.
1-1,2,3-三唑连接的硝基咪唑-异吲哚酮共轭物：合成、对接及对乳腺癌的抗增殖评估
ACS Omega. 2018 Sep 30;3(9):12106-12113. doi: 10.1021/acsomega.8b01513. Epub 2018 Sep 27.
4
Inhibitors against Fungal Cell Wall Remodeling Enzymes.抗真菌细胞壁重塑酶抑制剂。
ChemMedChem. 2018 Jan 22;13(2):128-132. doi: 10.1002/cmdc.201700720. Epub 2017 Dec 12.
5
Pd-Catalyzed Hydroamination of Alkoxyallenes with Azole Heterocycles: Examples and Mechanistic Proposal.钯催化的烷氧基丙二烯与唑杂环的氢胺化反应：实例与反应机理的建议。
Org Lett. 2017 Aug 18;19(16):4211-4214. doi: 10.1021/acs.orglett.7b01826. Epub 2017 Aug 8.
6
Tribenzyltin carboxylates as anticancer drug candidates: Effect on the cytotoxicity, motility and invasiveness of breast cancer cell lines.
Eur J Med Chem. 2017 Jan 5;125:770-783. doi: 10.1016/j.ejmech.2016.09.061. Epub 2016 Sep 21.
7
One-Pot Synthesis of Benzene-Fused Medium-Ring Ketones: Gold Catalysis-Enabled Enolate Umpolung Reactivity.一锅法合成苯并稠环酮：金催化促进烯醇负离子反转反应性。
J Am Chem Soc. 2016 May 4;138(17):5515-8. doi: 10.1021/jacs.6b02533. Epub 2016 Apr 22.
8
Small molecule glycoconjugates with anticancer activity.具有抗癌活性的小分子糖缀合物。
Eur J Med Chem. 2016 Apr 13;112:130-144. doi: 10.1016/j.ejmech.2016.01.061. Epub 2016 Feb 8.
9
An organocatalytic azide-aldehyde [3+2] cycloaddition: high-yielding regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles.有机催化叠氮-醛[3+2]环加成反应：高产率区域选择性合成 1,4-二取代 1,2,3-三唑。
Angew Chem Int Ed Engl. 2014 Sep 22;53(39):10420-4. doi: 10.1002/anie.201406721. Epub 2014 Jul 30.
10
Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: a case of clofilium analogues.通过刚性去除人 Ether-à-go-go 相关基因 (hERG) K+通道亲和力：氯菲立胺类似物的一个案例。
J Med Chem. 2013 Dec 12;56(23):9427-40. doi: 10.1021/jm4010434. Epub 2013 Nov 25.