Fisher Kristy A, Patel Poonam, Abualula Samer, Concepion Livasky
Psychiatry, Aventura Hospital and Medical Center, Aventura, USA.
Psychiatry, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA.
Cureus. 2021 Apr 7;13(4):e14356. doi: 10.7759/cureus.14356.
St. John's wort, a non-FDA-approved over-the-counter (OTC) herbal supplement with antidepressant activity known as , has been found to induce supraventricular tachycardia (SVT) in the absence of any underlying structural cardiac abnormality or known medical history via currently unclear pathophysiology. In this case presentation, the authors present a case of a 33-year-old female who presented with recurrent episodes of palpitations one month after initiating St. John's wort for the treatment of depression, which ultimately resolved upon cessation of the herbal supplement. Therefore, the postulated insinuating event is suspected to be the ingestion of St. John's wort. This will be the first documented case of St. John's wort-induced SVT. This case study brings into question the safety of the use of this agent as an OTC supplement for the management of depression. Further investigation is required to aid in the knowledge and understanding of the causative mechanism and to identify those patients who are at potentially heightened risks of such manifestations.
圣约翰草，一种未经美国食品药品监督管理局（FDA）批准的非处方（OTC）草本补充剂，具有抗抑郁活性，被称为贯叶连翘，已被发现可在无任何潜在结构性心脏异常或已知病史的情况下，通过目前尚不清楚的病理生理学机制诱发室上性心动过速（SVT）。在本病例报告中，作者介绍了一名33岁女性的病例，该女性在开始服用圣约翰草治疗抑郁症一个月后出现反复发作的心悸，在停用该草本补充剂后最终症状得到缓解。因此，推测的诱发事件被怀疑是摄入了圣约翰草。这将是首例有记录的圣约翰草诱发室上性心动过速的病例。本病例研究对将该药物用作治疗抑郁症的非处方补充剂的安全性提出了质疑。需要进一步研究以帮助了解其致病机制，并识别出那些可能有更高此类表现风险的患者。
