刺激响应型纳米气泡在生物医学中的应用。

Stimuli-responsive nanobubbles for biomedical applications.

机构信息

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, P. R. China.

Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230022, P. R. China and Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

出版信息

Chem Soc Rev. 2021 May 11;50(9):5746-5776. doi: 10.1039/c9cs00839j.

DOI:10.1039/c9cs00839j

PMID:33972972

Abstract

Stimuli-responsive nanobubbles have received increased attention for their application in spatial and temporal resolution of diagnostic techniques and therapies, particularly in multiple imaging methods, and they thus have significant potential for applications in the field of biomedicine. This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel applications. Properties of both internal- and external-stimuli responsive nanobubbles are highlighted and discussed considering the potential features required for biomedical applications. Furthermore, the methods used for synthesis and characterization of nanobubbles are outlined. Finally, novel biomedical applications are proposed alongside the advantages and shortcomings inherent to stimuli-responsive nanobubbles.

摘要

刺激响应纳米气泡因其在诊断技术和治疗的时空分辨率中的应用而受到越来越多的关注，特别是在多种成像方法中，因此它们在生物医学领域具有重要的应用潜力。本文综述了刺激响应纳米气泡的最新发展及其新应用。考虑到生物医学应用所需的潜在特性，强调和讨论了内部和外部刺激响应纳米气泡的特性。此外，概述了纳米气泡的合成和表征方法。最后，提出了刺激响应纳米气泡的新的生物医学应用以及其固有优缺点。